FOG00805
EOG8VHHNM

sce:VPH1

Genes: 33

Protein description
VATPase.V0.a


SGD Description
Subunit a of vacuolar-ATPase V0 domain; one of two isoforms (Vph1p and Stv1p); Vph1p is located in V-ATPase complexes of the vacuole while Stv1p is located in V-ATPase complexes of the Golgi and endosomes; relative distribution to the vacuolar membrane decreases upon DNA replication stress


PomBase Description
V-type ATPase V0 subunit a (predicted)


AspGD Description
Ortholog(s) have proton-transporting ATPase activity, rotational mechanism activity and role in endocytosis, polyphosphate metabolic process, protein complex assembly, proton transport, vacuolar acidification, vacuole organization


References

Manolson MF, et al. (1992 Jul 15). The VPH1 gene encodes a 95-kDa integral membrane polypeptide required for in vivo assembly and activity of the yeast vacuolar H(+)-ATPase.

Manolson MF, et al. (1992 Nov). Evidence for a conserved 95-120 kDa subunit associated with and essential for activity of V-ATPases.

Chéret G, et al. (1996 Sep). DNA sequence analysis of the VPH1-SNF2 region on chromosome XV of Saccharomyces cerevisiae.

Leng XH, et al. (1996 Sep 13). Site-directed mutagenesis of the 100-kDa subunit (Vph1p) of the yeast vacuolar (H+)-ATPase.

Leng XH, et al. (1998 Mar 20). Function of the COOH-terminal domain of Vph1p in activity and assembly of the yeast V-ATPase.

Leng XH, et al. (1999 May 21). Transmembrane topography of the 100-kDa a subunit (Vph1p) of the yeast vacuolar proton-translocating ATPase.

Landolt-Marticorena C, et al. (1999 Sep 10). Substrate- and inhibitor-induced conformational changes in the yeast V-ATPase provide evidence for communication between the catalytic and proton-translocating sectors.

Kawasaki-Nishi S, et al. (2001 May 25). Yeast V-ATPase complexes containing different isoforms of the 100-kDa a-subunit differ in coupling efficiency and in vivo dissociation.

Gachet Y, et al. (2005 Dec 1). btn1, the Schizosaccharomyces pombe homologue of the human Batten disease gene CLN3, regulates vacuole homeostasis.

Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.

Snaith HA, et al. (2011 Jul 1). Characterization of Mug33 reveals complementary roles for actin cable-dependent transport and exocyst regulators in fission yeast exocytosis.

Rhind N, et al. (2011 May 20). Comparative functional genomics of the fission yeasts.

Toei M, et al. (2011 Oct 7). Definition of membrane topology and identification of residues important for transport in subunit a of the vacuolar ATPase.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 33 genes with posterior transmembrane prediction > 50%

FOG00806
EOG8VHHNM

sce:STV1

Genes: 26

SGD Description
Subunit a of the vacuolar-ATPase V0 domain; one of two isoforms (Stv1p and Vph1p); Stv1p is located in V-ATPase complexes of the Golgi and endosomes while Vph1p is located in V-ATPase complexes of the vacuole


References

Manolson MF, et al. (1994 May 13). STV1 gene encodes functional homologue of 95-kDa yeast vacuolar H(+)-ATPase subunit Vph1p.

Kawasaki-Nishi S, et al. (2001 May 25). Yeast V-ATPase complexes containing different isoforms of the 100-kDa a-subunit differ in coupling efficiency and in vivo dissociation.

Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 26 genes with posterior transmembrane prediction > 50%