FOG00747
EOG87H491

sce:CYC1;CYC7

Genes: 36

SGD Description
Cytochrome c, isoform 1; also known as iso-1-cytochrome c; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; mutations in human homolog cause insulin-responsive hyperglycemia; CYC1 has a paralog, CYC7, that arose from the whole genome duplication|Cytochrome c isoform 2, expressed under hypoxic conditions; also known as iso-2-cytochrome c; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; protein abundance increases in response to DNA replication stress; CYC7 has a paralog, CYC1, that arose from the whole genome duplication


PomBase Description
cytochrome c


AspGD Description
Ortholog(s) have electron carrier activity, role in mitochondrial electron transport, cytochrome c to oxygen, mitochondrial electron transport, ubiquinol to cytochrome c and mitochondrial intermembrane space localization


References

Narita K, et al. (1969 Feb). The complete amino acid sequence in baker's yeast cytochrome c.

Sugeno K, et al. (1971 Oct). The amino acid sequence of cytochrome c from Debaryomyces kloeckeri.

Moroder L, et al. (1973 Apr). Studies on cytochrome c. 8. Synthesis of the protected hexadecapeptide (sequence 93-108) of Baker's yeast iso-1-cytochrome c.

Smith M, et al. (1979 Apr). Sequence of the gene for iso-1-cytochrome c in Saccharomyces cerevisiae.

Montgomery DL, et al. (1980 Jan). Isolation and sequence of the gene for iso-2-cytochrome c in Saccharomyces cerevisiae.

Boss JM, et al. (1981 Dec 25). Sequence of the yeast iso-1-cytochrome c mRNA.

McNeil JB, et al. (1986 Feb 5). Transcription initiation of the Saccharomyces cerevisiae iso-1-cytochrome c gene. Multiple, independent T-A-T-A sequences.

Park KS, et al. (1987 Oct 25). Enzymatic methylation of in vitro synthesized apocytochrome c enhances its transport into mitochondria.

Louie GV, et al. (1988 Jan 20). Yeast iso-1-cytochrome c. A 2.8 A resolution three-dimensional structure determination.

Louie GV, et al. (1990 Jul 20). High-resolution refinement of yeast iso-1-cytochrome c and comparisons with other eukaryotic cytochromes c.

Clark-Walker GD, et al. (1991 Aug). Contrasting mutation rates in mitochondrial and nuclear genes of yeasts versus mammals.

Murphy ME, et al. (1992 Sep 5). Structure determination and analysis of yeast iso-2-cytochrome c and a composite mutant protein.

Freire Picos MA, et al. (1993 Feb). Sequence of a cytochrome c gene from Kluyveromyces lactis and its upstream region.

Melnick L, et al. (1993 Oct 5). The gene clusters ARC and COR on chromosomes 5 and 10, respectively, of Saccharomyces cerevisiae share a common ancestry.

Huang ME, et al. (1994 Jun). Revised nucleotide sequence of the COR region of yeast Saccharomyces cerevisiae chromosome X.

Baistrocchi P, et al. (1996 Oct 29). Three-dimensional solution structure of Saccharomyces cerevisiae reduced iso-1-cytochrome c.

Janbon G, et al. (1997 Aug). Phylogenetic relationships of fungal cytochromes c.

Banci L, et al. (1997 Jul 22). Solution structure of oxidized Saccharomyces cerevisiae iso-1-cytochrome c.

Shi NQ, et al. (1999 Aug). Disruption of the cytochrome c gene in xylose-utilizing yeast Pichia stipitis leads to higher ethanol production.

Polevoda B, et al. (2000 Jul 7). Cytochrome c methyltransferase, Ctm1p, of yeast.

Kluck RM, et al. (2000 May 26). Determinants of cytochrome c pro-apoptotic activity. The role of lysine 72 trimethylation.

Lange C, et al. (2002 Mar 5). Crystal structure of the yeast cytochrome bc1 complex with its bound substrate cytochrome c.

Solmaz SR, et al. (2008 Jun 20). Structure of complex III with bound cytochrome c in reduced state and definition of a minimal core interface for electron transfer.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%