FOG00600
EOG8FXPR1
PDA1
sce:PDA1

Genes: 33

Protein description
E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex


SGD Description
E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex; catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA; phosphorylated; regulated by glucose; PDH complex is concentrated in spots within the mitochondrial matrix, often near the ERMES complex and near peroxisomes


PomBase Description
pyruvate dehydrogenase e1 component alpha subunit Pda1 (predicted)


AspGD Description
Alpha subunit E1 of the pyruvate dehydrogenase complex; induced by growth on starch and lactate


References

Romano AH, et al. (1968 Jun 24). Regulation of sugar utilization by Aspergillus nidulans.

Payton M, et al. (1976 May). Agar as a carbon source and its effect on the utilization of other carbon sources by acetate non-utilizing (acu) mutants of Aspergillus nidulans.

Payton MA, et al. (1977 Mar). Two unlinked genes for the pyruvate dehydrogenase complex in Aspergillus nidulans.

Bos CJ, et al. (1981 Nov). A third unlinked gene controlling the pyruvate dehydrogenase complex in Aspergillus nidulans.

Behal RH, et al. (1989 Oct 31). Nucleotide and deduced amino acid sequence of the alpha subunit of yeast pyruvate dehydrogenase.

Bishop DK, et al. (1992 May 1). DMC1: a meiosis-specific yeast homolog of E. coli recA required for recombination, synaptonemal complex formation, and cell cycle progression.

Kobayashi T, et al. (1993 Feb). Isolation and characterization of a yeast gene that is homologous with a meiosis-specific cDNA from a plant.

Wenzel TJ, et al. (1994 Mar). Promoter analysis of the PDA1 gene encoding the E1 alpha subunit of the pyruvate dehydrogenase complex from Saccharomyces cerevisiae.

Clutterbuck AJ, et al. (1997 Jun). The validity of the Aspergillus nidulans linkage map.

Zeeman AM, et al. (1998 Dec). Inactivation of the Kluyveromyces lactis KlPDA1 gene leads to loss of pyruvate dehydrogenase activity, impairs growth on glucose and triggers aerobic alcoholic fermentation.

Sims AH, et al. (2004 Aug). Combining transcriptome data with genomic and cDNA sequence alignments to make confident functional assignments for Aspergillus nidulans genes.

Gruhler A, et al. (2005 Mar). Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway.

Reinders J, et al. (2007 Nov). Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase.

Gey U, et al. (2008 Apr 11). Yeast pyruvate dehydrogenase complex is regulated by a concerted activity of two kinases and two phosphatases.

Shimizu M, et al. (2009 Jan). Proteomic analysis of Aspergillus nidulans cultured under hypoxic conditions.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Flipphi M, et al. (2009 Mar). Biodiversity and evolution of primary carbon metabolism in Aspergillus nidulans and other Aspergillus spp.

Singh NS, et al. (2011 Dec 6). SIN-inhibitory phosphatase complex promotes Cdc11p dephosphorylation and propagates SIN asymmetry in fission yeast.

Ren L, et al. (2011 Feb 28). Systematic two-hybrid and comparative proteomic analyses reveal novel yeast pre-mRNA splicing factors connected to Prp19.

Nie M, et al. (2012 Aug 24). Dual recruitment of Cdc48 (p97)-Ufd1-Npl4 ubiquitin-selective segregase by small ubiquitin-like modifier protein (SUMO) and ubiquitin in SUMO-targeted ubiquitin ligase-mediated genome stability functions.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Lucena R, et al. (2015 May 11). Nucleocytoplasmic transport in the midzone membrane domain controls yeast mitotic spindle disassembly.

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG00601
EOG8FXPR1

sce:absent

Genes: 1

Parent
paralog:FOG00600


AspGD Description
Pyruvate dehydrogenase complex E1-alpha subunit

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%