FOG00220
EOG8VX0MD
sce:RAD54
Genes: 32
EOG8VX0MD
sce:RAD54
Genes: 32
Protein description
DNA repair
SGD Description
DNA-dependent ATPase that stimulates strand exchange; modifies the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family of DNA translocases; forms nuclear foci upon DNA replication stress
PomBase Description
DNA-dependent ATPase Rad54/Rhp54
AspGD Description
Ortholog(s) have role in DNA repair, ascospore formation, meiotic gene conversion, reciprocal meiotic recombination and mitotic spindle, nucleus, site of double-strand break localization
References
Emery HS, et al. (1991 Jul 31). Sequence of RAD54, a Saccharomyces cerevisiae gene involved in recombination and repair.
Johnston LH, et al. (1995 Jun 25). The DNA repair genes RAD54 and UNG1 are cell cycle regulated in budding yeast but MCB promoter elements have no essential role in the DNA damage response.
Petukhova G, et al. (1998 May 7). Catalysis of homologous DNA pairing by yeast Rad51 and Rad54 proteins.
Solinger JA, et al. (2002 Nov). Rad54, a Swi2/Snf2-like recombinational repair protein, disassembles Rad51:dsDNA filaments.
| Mitochondrial localization predictions | ||
|---|---|---|
| Predotar | TargetP | MitoProt |
 |
 |
 |
| Raw data
|
||
| Phobius transmembrane predictions
3 genes with posterior transmembrane prediction > 50% |
||
FOG00221
EOG8VX0MD
sce:RAD26
Genes: 32
EOG8VX0MD
sce:RAD26
Genes: 32
Protein description
DNA repair
SGD Description
Protein involved in transcription-coupled nucleotide excision repair; repairs UV-induced DNA lesions; recruitment to DNA lesions is dependent on an elongating RNA polymerase II; homolog of human CSB protein
PomBase Description
SNF2 family ATP-dependent DNA helicase Rhp26
AspGD Description
Ortholog(s) have role in transcription-coupled nucleotide-excision repair and cytosol, nucleus localization
References
Huang ME, et al. (1994 May 30). A possible yeast homolog of human active-gene-repairing helicase ERCC6+.
van Gool AJ, et al. (1994 Nov 15). RAD26, the functional S. cerevisiae homolog of the Cockayne syndrome B gene ERCC6.
Yasuhira S, et al. (1999 Sep 17). Transcription dependence and the roles of two excision repair pathways for UV damage in fission yeast Schizosaccharomyces pombe.
Marti TM, et al. (2003 Jun). Repair of damaged and mismatched DNA by the XPC homologues Rhp41 and Rhp42 of fission yeast.
Fukumoto Y, et al. (2008 Nov). Schizosaccharomyces pombe Ddb1 recruits substrate-specific adaptor proteins through a novel protein motif, the DDB-box.
Jaakkola E, et al. (2010 Dec). ERCC6 founder mutation identified in Finnish patients with COFS syndrome.
Kanamitsu K, et al. (2011). Fission yeast homologs of human XPC and CSB, rhp41 and rhp26, are involved in transcription-coupled repair of methyl methanesulfonate-induced DNA damage.
Latypov VF, et al. (2012 Jul 13). Atl1 regulates choice between global genome and transcription-coupled repair of O(6)-alkylguanines.
Wang L, et al. (2014 Dec 30). Regulation of the Rhp26ERCC6/CSB chromatin remodeler by a novel conserved leucine latch motif.
Guo Y, et al. (2014 Jul). Large scale screening of genetic interaction with sgf73(+) in fission yeast.
Ding L, et al. (2014 May 28). Essential domains of Schizosaccharomyces pombe Rad8 required for DNA damage response.
Dudin O, et al. (2017 Apr). A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.
| Mitochondrial localization predictions | ||
|---|---|---|
| Predotar | TargetP | MitoProt |
 |
 |
 |
| Raw data
|
||
| Phobius transmembrane predictions
1 genes with posterior transmembrane prediction > 50% |
||
FOG00222
EOG8VX0MD
sce:RDH54
Genes: 31
EOG8VX0MD
sce:RDH54
Genes: 31
Protein description
DNA repair
SGD Description
DNA-dependent ATPase; DNA recombination/repair translocase, supercoils DNA and promotes DNA strand opening; stimulates strand exchange by modifying dsDNA topology; involved in recombinational repair of DNA double-strand breaks (DSBs) during mitosis and meiosis; phosphorylated in Mec1p-, Rad53p-dependent way in response to one DSB; contributes to remodelling of nucleosomes; proposed to be involved in crossover interference; interacts with Dmc1p; stimulates Dmc1p and Rad51p
PomBase Description
ATP-dependent DNA helicase Rdh54
AspGD Description
Ortholog(s) have DNA translocase activity, double-stranded DNA binding activity and role in DNA duplex unwinding, DNA repair, heteroduplex formation, meiotic sister chromatid segregation, reciprocal meiotic recombination
References
Klein HL, et al. (1997 Dec). RDH54, a RAD54 homologue in Saccharomyces cerevisiae, is required for mitotic diploid-specific recombination and repair and for meiosis.
Shinohara M, et al. (1997 Dec). Characterization of the roles of the Saccharomyces cerevisiae RAD54 gene and a homologue of RAD54, RDH54/TID1, in mitosis and meiosis.
Dresser ME, et al. (1997 Oct). DMC1 functions in a Saccharomyces cerevisiae meiotic pathway that is largely independent of the RAD51 pathway.
Petukhova G, et al. (2000 Sep 1). Promotion of Rad51-dependent D-loop formation by yeast recombination factor Rdh54/Tid1.
Shinohara M, et al. (2000 Sep 26). Tid1/Rdh54 promotes colocalization of rad51 and dmc1 during meiotic recombination.
Lee SE, et al. (2001 Jul 10). The Saccharomyces recombination protein Tid1p is required for adaptation from G2/M arrest induced by a double-strand break.
Shinohara M, et al. (2003 Apr). Crossover interference in Saccharomyces cerevisiae requires a TID1/RDH54- and DMC1-dependent pathway.
Kellis M, et al. (2003 May 15). Sequencing and comparison of yeast species to identify genes and regulatory elements.
Catlett MG, et al. (2003 Nov). Schizosaccharomyces pombe Rdh54 (TID1) acts with Rhp54 (RAD54) to repair meiotic double-strand breaks.
Goldman GH, et al. (2004 Apr). Aspergillus nidulans as a model system to characterize the DNA damage response in eukaryotes.
Martín-Castellanos C, et al. (2005 Nov 22). A large-scale screen in S. pombe identifies seven novel genes required for critical meiotic events.
Malavazi I, et al. (2007 Oct). Transcriptome analysis of the Aspergillus nidulans AtmA (ATM, Ataxia-Telangiectasia mutated) null mutant.
Chi P, et al. (2009 Feb 1). Functional interactions of meiotic recombination factors Rdh54 and Dmc1.
Tougan T, et al. (2010 Dec 1). The Mek1 phosphorylation cascade plays a role in meiotic recombination of Schizosaccharomyces pombe.
Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.
Mastro TL, et al. (2014 Dec). Increased meiotic crossovers and reduced genome stability in absence of Schizosaccharomyces pombe Rad16 (XPF).
Guo Y, et al. (2014 Jul). Large scale screening of genetic interaction with sgf73(+) in fission yeast.
Graml V, et al. (2014 Oct 27). A genomic Multiprocess survey of machineries that control and link cell shape, microtubule organization, and cell-cycle progression.
Mojardín L, et al. (2015). Chromosome segregation and organization are targets of 5'-Fluorouracil in eukaryotic cells.
| Mitochondrial localization predictions | ||
|---|---|---|
| Predotar | TargetP | MitoProt |
 |
 |
 |
| Raw data
|
||
| Phobius transmembrane predictions
2 genes with posterior transmembrane prediction > 50% |
||
FOG00223
EOG8VX0MD
sce:absent
Genes: 1
EOG8VX0MD
sce:absent
Genes: 1
Protein description
Uncharacterized paralog / ohnolog
Parent
ohnolog?:FOG00222
| Mitochondrial localization predictions | ||
|---|---|---|
| Predotar | TargetP | MitoProt |
 |
 |
 |
| Raw data
|
||
| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
||
