FOG00210
EOG8CZ8X8

sce:RAD30

Genes: 33

Protein description
DNA polymerase eta


SGD Description
DNA polymerase eta; involved in translesion synthesis during post-replication repair; catalyzes the synthesis of DNA opposite cyclobutane pyrimidine dimers and other lesions; involved in formation of post-replicative damage-induced genome-wide cohesion; may also have a role in protection against mitochondrial mutagenesis; mutations in human pol eta are responsible for XPV


PomBase Description
sister chromatid cohesion protein/DNA polymerase eta Eso1 fusion protein


AspGD Description
Ortholog(s) have peptidyl-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor activity


References

McDonald JP, et al. (1997 Dec). The Saccharomyces cerevisiae RAD30 gene, a homologue of Escherichia coli dinB and umuC, is DNA damage inducible and functions in a novel error-free postreplication repair mechanism.

Washington MT, et al. (1999 Dec 24). Fidelity and processivity of Saccharomyces cerevisiae DNA polymerase eta.

Johnson RE, et al. (1999 Feb 12). Efficient bypass of a thymine-thymine dimer by yeast DNA polymerase, Poleta.

Johnson RE, et al. (1999 Jun 4). Requirement of DNA polymerase activity of yeast Rad30 protein for its biological function.

Haracska L, et al. (2000 Aug). Efficient and accurate replication in the presence of 7,8-dihydro-8-oxoguanine by DNA polymerase eta.

Xiao W, et al. (2000 Aug). The Saccharomyces cerevisiae RAD6 group is composed of an error-prone and two error-free postreplication repair pathways.

Yuan F, et al. (2000 Mar 17). Specificity of DNA lesion bypass by the yeast DNA polymerase eta.

Washington MT, et al. (2000 Mar 28). Accuracy of thymine-thymine dimer bypass by Saccharomyces cerevisiae DNA polymerase eta.

Haracska L, et al. (2000 Nov). Replication past O(6)-methylguanine by yeast and human DNA polymerase eta.

Haracska L, et al. (2001 Aug). Interaction with PCNA is essential for yeast DNA polymerase eta function.

Trincao J, et al. (2001 Aug). Structure of the catalytic core of S. cerevisiae DNA polymerase eta: implications for translesion DNA synthesis.

Yu SL, et al. (2001 Jan). Requirement of DNA polymerase eta for error-free bypass of UV-induced CC and TC photoproducts.

Washington MT, et al. (2001 Jan 19). Mismatch extension ability of yeast and human DNA polymerase eta.

Minko IG, et al. (2001 Jan 26). Translesion DNA synthesis by yeast DNA polymerase eta on templates containing N2-guanine adducts of 1,3-butadiene metabolites.

Kondratick CM, et al. (2001 Mar). Acidic residues critical for the activity and biological function of yeast DNA polymerase eta.

Bresson A, et al. (2002 Jul 15). Lesion bypass in yeast cells: Pol eta participates in a multi-DNA polymerase process.

Zhang H, et al. (2002 Mar 1). UV-induced T-->C transition at a TT photoproduct site is dependent on Saccharomyces cerevisiae polymerase eta in vivo.

Johnson RE, et al. (2003 Apr). Deoxynucleotide triphosphate binding mode conserved in Y family DNA polymerases.

Washington MT, et al. (2003 Apr 29). Yeast DNA polymerase eta makes functional contacts with the DNA minor groove only at the incoming nucleoside triphosphate.

Kozmin SG, et al. (2003 Aug 1). Roles of Saccharomyces cerevisiae DNA polymerases Poleta and Polzeta in response to irradiation by simulated sunlight.

Sun L, et al. (2003 Aug 12). Yeast pol eta holds a cis-syn thymine dimer loosely in the active site during elongation opposite the 3'-T of the dimer, but tightly opposite the 5'-T.

Washington MT, et al. (2003 Oct 14). Mechanism of nucleotide incorporation opposite a thymine-thymine dimer by yeast DNA polymerase eta.

McCulloch SD, et al. (2004). Enzymatic switching for efficient and accurate translesion DNA replication.

Zhao B, et al. (2004). Role of DNA polymerase eta in the bypass of abasic sites in yeast cells.

Goldman GH, et al. (2004 Apr). Aspergillus nidulans as a model system to characterize the DNA damage response in eukaryotes.

Niimi A, et al. (2004 Apr). Palm mutants in DNA polymerases alpha and eta alter DNA replication fidelity and translesion activity.

Gu C, et al. (2004 Jun 1). LC-MS/MS identification and yeast polymerase eta bypass of a novel gamma-irradiation-induced intrastrand cross-link lesion G[8-5]C.

Hwang H, et al. (2004 Nov 23). Role of base stacking and sequence context in the inhibition of yeast DNA polymerase eta by pyrene nucleotide.

Michán C, et al. (2005 Apr 4). Transcript copy number of genes for DNA repair and translesion synthesis in yeast: contribution of transcription rate and mRNA stability to the steady-state level of each mRNA along with growth in glucose-fermentative medium.

Ober M, et al. (2005 Dec 28). Base pairing and replicative processing of the formamidopyrimidine-dG DNA lesion.

Xie Z, et al. (2005 Dec 8). The p-benzoquinone DNA adducts derived from benzene are highly mutagenic.

Gibbs PE, et al. (2005 Feb). The relative roles in vivo of Saccharomyces cerevisiae Pol eta, Pol zeta, Rev1 protein and Pol32 in the bypass and mutation induction of an abasic site, T-T (6-4) photoadduct and T-T cis-syn cyclobutane dimer.

Carlson KD, et al. (2005 Mar). Mechanism of efficient and accurate nucleotide incorporation opposite 7,8-dihydro-8-oxoguanine by Saccharomyces cerevisiae DNA polymerase eta.

Hwang H, et al. (2005 Mar 29). Evidence for Watson-Crick and not Hoogsteen or wobble base pairing in the selection of nucleotides for insertion opposite pyrimidines and a thymine dimer by yeast DNA pol eta.

Zhao B, et al. (2006). Poleta, Polzeta and Rev1 together are required for G to T transversion mutations induced by the (+)- and (-)-trans-anti-BPDE-N2-dG DNA adducts in yeast cells.

Vu B, et al. (2006 Aug 1). DNA synthesis past a 5-methylC-containing cis-syn-cyclobutane pyrimidine dimer by yeast pol eta is highly nonmutagenic.

Abdulovic AL, et al. (2006 Mar). The in vivo characterization of translesion synthesis across UV-induced lesions in Saccharomyces cerevisiae: insights into Pol zeta- and Pol eta-dependent frameshift mutagenesis.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%