FOG00010
EOG8CRJJ9
RPL8
sce:RPL8A;RPL8B

Genes: 51

Protein description
RPL8 Large ribosome protein subunit


SGD Description
Ribosomal 60S subunit protein L8A; required for processing of 27SA3 pre-rRNA to 27SB pre-rRNA during assembly of large ribosomal subunit; depletion leads to a turnover of pre-rRNA; L8 binds to Domain I of 25S and 5.8 S rRNAs; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8A has a paralog, RPL8B, that arose from the whole genome duplication|Ribosomal 60S subunit protein L8B; required for processing of 27SA3 pre-rRNA to 27SB pre-rRNA during assembly of large ribosomal subunit; depletion leads to a turnover of pre-rRNA; L8 binds to Domain I of 25S and 5.8 S rRNAs; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8B has a paralog, RPL8A, that arose from the whole genome duplication


PomBase Description
60S ribosomal protein L7a/L8 (predicted)


AspGD Description
Ortholog(s) have role in maturation of LSU-rRNA and cytosolic large ribosomal subunit localization


References

Wickner RB, et al. (1976 Aug 15). Chromosomal genes essential for replication of a double-stranded RNA plasmid of Saccharomyces cerevisiae: the killer character of yeast.

Arevalo SG, et al. (1990 Mar 25). Ribosomal protein L4 of Saccharomyces cerevisiae: the gene and its protein.

Yon J, et al. (1991 May). The organization and expression of the Saccharomyces cerevisiae L4 ribosomal protein genes and their identification as the homologues of the mammalian ribosomal protein gene L7a.

Takakura H, et al. (1992 Mar 15). NH2-terminal acetylation of ribosomal proteins of Saccharomyces cerevisiae.

Cusick ME, et al. (1994 Jan 18). Purification and identification of two major single-stranded binding proteins of yeast Saccharomyces cerevisiae as ribosomal protein L4 and histone H2B.

Cusick ME, et al. (1994 Mar 11). RNP1, a new ribonucleoprotein gene of the yeast Saccharomyces cerevisiae.

Ohtake Y, et al. (1995 May). Yeast virus propagation depends critically on free 60S ribosomal subunit concentration.

Planta RJ, et al. (1998 Mar 30). The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae.

Arnold RJ, et al. (1999 Dec 24). The action of N-terminal acetyltransferases on yeast ribosomal proteins.

Spahn CM, et al. (2001 Nov 2). Structure of the 80S ribosome from Saccharomyces cerevisiae--tRNA-ribosome and subunit-subunit interactions.

Spahn CM, et al. (2004 Mar 10). Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation.

Ben-Shem A, et al. (2010 Nov 26). Crystal structure of the eukaryotic ribosome.

Ben-Shem A, et al. (2011 Dec 16). The structure of the eukaryotic ribosome at 3.0 Å resolution.

Ban N, et al. (2014 Feb). A new system for naming ribosomal proteins.

Murray J, et al. (2016 May 9). Structural characterization of ribosome recruitment and translocation by type IV IRES.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%