FOG19642
EOG800004

sce:NMD2

Genes: 32

SGD Description
Protein involved in the nonsense-mediated mRNA decay (NMD) pathway; interacts with Nam7p and Upf3p; involved in telomere maintenance


PomBase Description
nonsense-mediated decay protein Upf2


AspGD Description
Ortholog(s) have role in DNA recombination, mRNA stabilization, nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay and cytosol, polysome localization


References

Cui Y, et al. (1995 Feb 15). Identification and characterization of genes that are required for the accelerated degradation of mRNAs containing a premature translational termination codon.

He F, et al. (1995 Feb 15). Identification of a novel component of the nonsense-mediated mRNA decay pathway by use of an interacting protein screen.

Lee SI, et al. (1995 Jul 3). A genetic screen identifies cellular factors involved in retroviral -1 frameshifting.

Mendell JT, et al. (2000 Dec). Novel Upf2p orthologues suggest a functional link between translation initiation and nonsense surveillance complexes.

Morozov IY, et al. (2006 Nov). Nonsense-mediated mRNA decay mutation in Aspergillus nidulans.

Rodríguez-Gabriel MA, et al. (2006 Sep). Upf1, an RNA helicase required for nonsense-mediated mRNA decay, modulates the transcriptional response to oxidative stress in fission yeast.

Wen J, et al. (2010 May 5). Splicing-dependent NMD does not require the EJC in Schizosaccharomyces pombe.

Chen JS, et al. (2014 Dec 31). Identification of new players in cell division, DNA damage response, and morphogenesis through construction of Schizosaccharomyces pombe deletion strains.

Hayashi T, et al. (2014 Jul). Schizosaccharomyces pombe centromere protein Mis19 links Mis16 and Mis18 to recruit CENP-A through interacting with NMD factors and the SWI/SNF complex.

Malecki M, et al. (2016). Identifying genes required for respiratory growth of fission yeast.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 15 genes with posterior transmembrane prediction > 50%