FOG19604
EOG802V7R

sce:ABP1

Genes: 34

SGD Description
Actin-binding protein of the cortical actin cytoskeleton; important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization; inhibits barbed-end actin filament elongation; phosphorylation within its Proline-Rich Regio, mediated by Cdc28p and Pho85p, protects Abp1p from proteolysis mediated by its own PEST sequences; mammalian homologue of HIP-55 (hematopoietic progenitor kinase 1 [HPK1]-interacting protein of 55 kDa)


PomBase Description
cofilin/tropomyosin family, drebrin ortholog Abp1


AspGD Description
Predicted actin-binding protein involved in endocytosis


References

Drubin DG, et al. (1990 Jan 18). Homology of a yeast actin-binding protein to signal transduction proteins and myosin-I.

Freeman NL, et al. (1996 Feb). A conserved proline-rich region of the Saccharomyces cerevisiae cyclase-associated protein binds SH3 domains and modulates cytoskeletal localization.

Colwill K, et al. (1999 Jul). In vivo analysis of the domains of yeast Rvs167p suggests Rvs167p function is mediated through multiple protein interactions.

Goode BL, et al. (2001 Apr 30). Activation of the Arp2/3 complex by the actin filament binding protein Abp1p.

Pelham RJ Jr, et al. (2001 Mar). Role of actin polymerization and actin cables in actin-patch movement in Schizosaccharomyces pombe.

Warren DT, et al. (2002 Apr 15). Sla1p couples the yeast endocytic machinery to proteins regulating actin dynamics.

Fazi B, et al. (2002 Feb 15). Unusual binding properties of the SH3 domain of the yeast actin-binding protein Abp1: structural and functional analysis.

Landgraf C, et al. (2004 Jan). Protein interaction networks by proteome peptide scanning.

Quintero-Monzon O, et al. (2005 Jul). Structural and functional dissection of the Abp1 ADFH actin-binding domain reveals versatile in vivo adapter functions.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Taheri-Talesh N, et al. (2008 Apr). The tip growth apparatus of Aspergillus nidulans.

Araujo-Bazán L, et al. (2008 Feb). Preferential localization of the endocytic internalization machinery to hyphal tips underlies polarization of the actin cytoskeleton in Aspergillus nidulans.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Sirotkin V, et al. (2010 Aug 15). Quantitative analysis of the mechanism of endocytic actin patch assembly and disassembly in fission yeast.

Hervás-Aguilar A, et al. (2010 Oct). Endocytic machinery protein SlaB is dispensable for polarity establishment but necessary for polarity maintenance in hyphal tip cells of Aspergillus nidulans.

Bitsikas V, et al. (2011 Jan). Hypertonic conditions trigger transient plasmolysis, growth arrest and blockage of transporter endocytosis in Aspergillus nidulans and Saccharomyces cerevisiae.

Shaw BD, et al. (2011 Jun). A role for endocytic recycling in hyphal growth.

Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Chen JS, et al. (2013 May). Comprehensive proteomics analysis reveals new substrates and regulators of the fission yeast clp1/cdc14 phosphatase.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Laporte D, et al. (2015 Jul 6). A stable microtubule array drives fission yeast polarity reestablishment upon quiescence exit.

Swaffer MP, et al. (2016 Dec 15). CDK Substrate Phosphorylation and Ordering the Cell Cycle.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%