FOG19567
EOG805QG2

sce:TOF1

Genes: 32

SGD Description
Subunit of a replication-pausing checkpoint complex; Tof1p-Mrc1p-Csm3p acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA; interacts with the MCM helicase; relocalizes to the cytosol in response to hypoxia


PomBase Description
replication fork protection complex subunit Swi1


AspGD Description
Ortholog(s) have DNA binding activity


References

Egel R, et al. (1981 Apr). Gene activation by copy transposition in mating-type switching of a homothallic fission yeast.

Egel R, et al. (1984 Jun). Genes required for initiation and resolution steps of mating-type switching in fission yeast.

Gutz H, et al. (1985). Switching genes in Schizosaccharomyces pombe.

Schmidt H, et al. (1987 Dec). Strains of Schizosaccharomyces pombe with a disrupted swi1 gene still show some mating-type switching.

Park H, et al. (1999 Jan 15). Identification and characterization of the genes for two topoisomerase I-interacting proteins from Saccharomyces cerevisiae.

Foss EJ, et al. (2001 Feb). Tof1p regulates DNA damage responses during S phase in Saccharomyces cerevisiae.

Nakayama Ji, et al. (2001 Jun 1). A role for DNA polymerase alpha in epigenetic control of transcriptional silencing in fission yeast.

Katou Y, et al. (2003 Aug 28). S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex.

Codlin S, et al. (2003 Jul 1). Complex mechanism of site-specific DNA replication termination in fission yeast.

Noguchi E, et al. (2003 Nov). Swi1 prevents replication fork collapse and controls checkpoint kinase Cds1.

O'Neill BM, et al. (2004). Coordinated functions of WSS1, PSY2 and TOF1 in the DNA damage response.

Mayer ML, et al. (2004 Apr). Identification of protein complexes required for efficient sister chromatid cohesion.

Vengrova S, et al. (2004 Apr 1). RNase-sensitive DNA modification(s) initiates S. pombe mating-type switching.

Lee BS, et al. (2004 Nov). Biochemical interactions between proteins and mat1 cis-acting sequences required for imprinting in fission yeast.

Noguchi E, et al. (2004 Oct). Swi1 and Swi3 are components of a replication fork protection complex in fission yeast.

Sommariva E, et al. (2005 Apr). Schizosaccharomyces pombe Swi1, Swi3, and Hsk1 are components of a novel S-phase response pathway to alkylation damage.

Nedelcheva MN, et al. (2005 Apr 1). Uncoupling of unwinding from DNA synthesis implies regulation of MCM helicase by Tof1/Mrc1/Csm3 checkpoint complex.

Archambault V, et al. (2005 Aug). Disruption of mechanisms that prevent rereplication triggers a DNA damage response.

Matsumoto S, et al. (2005 Dec 30). Hsk1-Dfp1/Him1, the Cdc7-Dbf4 kinase in Schizosaccharomyces pombe, associates with Swi1, a component of the replication fork protection complex.

Tourrière H, et al. (2005 Sep 2). Mrc1 and Tof1 promote replication fork progression and recovery independently of Rad53.

Redon C, et al. (2006 Jan). Genetic analysis of Saccharomyces cerevisiae H2A serine 129 mutant suggests a functional relationship between H2A and the sister-chromatid cohesion partners Csm3-Tof1 for the repair of topoisomerase I-induced DNA damage.

Mohanty BK, et al. (2006 Jan 24). The Tof1p-Csm3p protein complex counteracts the Rrm3p helicase to control replication termination of Saccharomyces cerevisiae.

Martín V, et al. (2006 Jun 7). Sws1 is a conserved regulator of homologous recombination in eukaryotic cells.

Chin JK, et al. (2006 May 10). Esc4/Rtt107 and the control of recombination during replication.

Noguchi C, et al. (2007 Feb). Sap1 promotes the association of the replication fork protection complex with chromatin and is involved in the replication checkpoint in Schizosaccharomyces pombe.

Shikata M, et al. (2007 Feb 23). Tel2 is required for activation of the Mrc1-mediated replication checkpoint.

Xhemalce B, et al. (2007 Jan 16). Role of SUMO in the dynamics of telomere maintenance in fission yeast.

Dovey CL, et al. (2007 Sep). Mms22 preserves genomic integrity during DNA replication in Schizosaccharomyces pombe.

Ansbach AB, et al. (2008 Feb). RFCCtf18 and the Swi1-Swi3 complex function in separate and redundant pathways required for the stabilization of replication forks to facilitate sister chromatid cohesion in Schizosaccharomyces pombe.

Yin L, et al. (2008 Oct). Activation of the DNA damage checkpoint in mutants defective in DNA replication initiation.

Eydmann T, et al. (2008 Sep). Rtf1-mediated eukaryotic site-specific replication termination.

Willis N, et al. (2009 Feb). Mus81, Rhp51(Rad51), and Rqh1 form an epistatic pathway required for the S-phase DNA damage checkpoint.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Pryce DW, et al. (2009 Mar 24). Recombination at DNA replication fork barriers is not universal and is differentially regulated by Swi1.

Willis N, et al. (2010 Apr). The fission yeast Rad32(Mre11)-Rad50-Nbs1 complex acts both upstream and downstream of checkpoint signaling in the S-phase DNA damage checkpoint.

Matsumoto S, et al. (2010 Dec 1). Hsk1 kinase and Cdc45 regulate replication stress-induced checkpoint responses in fission yeast.

Tanaka T, et al. (2010 Dec 17). Fission yeast Swi1-Swi3 complex facilitates DNA binding of Mrc1.

Rozenzhak S, et al. (2010 Jul 22). Rad3 decorates critical chromosomal domains with gammaH2A to protect genome integrity during S-Phase in fission yeast.

Dolan WP, et al. (2010 May). Fission yeast Hsk1 (Cdc7) kinase is required after replication initiation for induced mutagenesis and proper response to DNA alkylation damage.

Rapp JB, et al. (2010 Oct 12). Checkpoint-dependent and -independent roles of Swi3 in replication fork recovery and sister chromatid cohesion in fission yeast.

Cavero S, et al. (2010 Sep 23). Critical functions of Rpa3/Ssb3 in S-phase DNA damage responses in fission yeast.

Akai Y, et al. (2011 Dec). Opposing role of condensin hinge against replication protein A in mitosis and interphase through promoting DNA annealing.

Hayano M, et al. (2011 Jun). Mrc1 marks early-firing origins and coordinates timing and efficiency of initiation in fission yeast.

Vejrup-Hansen R, et al. (2011 Mar 7). Schizosaccharomyces pombe Mms1 channels repair of perturbed replication into Rhp51 independent homologous recombination.

Noguchi C, et al. (2012). Swi1 associates with chromatin through the DDT domain and recruits Swi3 to preserve genomic integrity.

Holmes A, et al. (2012 Dec 27). Lsd1 and lsd2 control programmed replication fork pauses and imprinting in fission yeast.

Garabedian MV, et al. (2012 Feb). The double-bromodomain proteins Bdf1 and Bdf2 modulate chromatin structure to regulate S-phase stress response in Schizosaccharomyces pombe.

Sabouri N, et al. (2012 Mar 15). DNA replication through hard-to-replicate sites, including both highly transcribed RNA Pol II and Pol III genes, requires the S. pombe Pfh1 helicase.

Sánchez A, et al. (2012 Nov). Replication fork collapse and genome instability in a deoxycytidylate deaminase mutant.

Roseaulin LC, et al. (2013). Coordinated degradation of replisome components ensures genome stability upon replication stress in the absence of the replication fork protection complex.

Schonbrun M, et al. (2013 Jul 5). TORC2 is required to maintain genome stability during S phase in fission yeast.

Wang J, et al. (2013 Sep 1). Epe1 recruits BET family bromodomain protein Bdf2 to establish heterochromatin boundaries.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Ding L, et al. (2014 May 28). Essential domains of Schizosaccharomyces pombe Rad8 required for DNA damage response.

Sánchez A, et al. (2015). Ku stabilizes replication forks in the absence of Brc1.

Gadaleta MC, et al. (2016 Mar). Swi1Timeless Prevents Repeat Instability at Fission Yeast Telomeres.

Ranatunga NS, et al. (2016 Oct 13). Characterization of a Novel MMS-Sensitive Allele of Schizosaccharomyces pombe mcm4.

Noguchi C, et al. (2017 Jan 2). Genetic controls of DNA damage avoidance in response to acetaldehyde in fission yeast.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 20 genes with posterior transmembrane prediction > 50%