FOG19475
EOG80CG0C

sce:CDC37

Genes: 32

SGD Description
Essential Hsp90p co-chaperone; necessary for passage through the START phase of the cell cycle; stabilizes protein kinase nascent chains and participates along with Hsp90p in their folding


PomBase Description
Hsp90 co-chaperone Cdc37


AspGD Description
Ortholog(s) have heat shock protein binding activity, role in protein folding and cytosol, nucleus localization


References

Ferguson J, et al. (1986 Aug 26). Nucleotide sequence of the yeast cell division cycle start genes CDC28, CDC36, CDC37, and CDC39, and a structural analysis of the predicted products.

Gerber MR, et al. (1995 May 9). Cdc37 is required for association of the protein kinase Cdc28 with G1 and mitotic cyclins.

Farrell A, et al. (2000 Feb). Cdc37 promotes the stability of protein kinases Cdc28 and Cak1.

Abbas-Terki T, et al. (2000 Feb 4). The molecular chaperone Cdc37 is required for Ste11 function and pheromone-induced cell cycle arrest.

Tatebe H, et al. (2003 Aug). Identification of Cdc37 as a novel regulator of the stress-responsive mitogen-activated protein kinase.

Westwood PK, et al. (2004 Feb). Fission yeast Cdc37 is required for multiple cell cycle functions.

Turnbull EL, et al. (2005 Aug). Cdc37 maintains cellular viability in Schizosaccharomyces pombe independently of interactions with heat-shock protein 90.

Turnbull EL, et al. (2006 Jan 15). Activity of Cdc2 and its interaction with the cyclin Cdc13 depend on the molecular chaperone Cdc37 in Schizosaccharomyces pombe.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Liang J, et al. (2007 Jul). The Schizosaccharomyces pombe Cdc7 protein kinase required for septum formation is a client protein of Cdc37.

Hawle P, et al. (2007 Mar). Cdc37p is required for stress-induced high-osmolarity glycerol and protein kinase C mitogen-activated protein kinase pathway functionality by interaction with Hog1p and Slt2p (Mpk1p).

Wilson-Grady JT, et al. (2008 Mar). Phosphoproteome analysis of fission yeast.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Kim Y, et al. (2011 Nov). Autophagy induced by rapamycin and carbon-starvation have distinct proteome profiles in Aspergillus nidulans.

Nie M, et al. (2012 Aug 24). Dual recruitment of Cdc48 (p97)-Ufd1-Npl4 ubiquitin-selective segregase by small ubiquitin-like modifier protein (SUMO) and ubiquitin in SUMO-targeted ubiquitin ligase-mediated genome stability functions.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%