FOG19284
EOG80ZPCC

sce:ATG2

Genes: 34

SGD Description
Peripheral membrane protein required for autophagic vesicle formation; also required for vesicle formation during pexophagy and the cytoplasm-to-vaucole targeting (Cvt) pathway; involved in Atg9p cycling between the phagophore assembly site and mitochondria; essential for cell cycle progression from G2/M to G1 under nitrogen starvation; forms cytoplasmic foci upon DNA replication stress


PomBase Description
autophagy associated protein Atg2


AspGD Description
Putative membrane protein involved in autophagy


References

Tsukada M, et al. (1993 Oct 25). Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae.

Saiz JE, et al. (1999 Jan 30). Disruption of six unknown open reading frames from Saccharomyces cerevisiae reveals two genes involved in vacuolar morphogenesis and one gene required for sporulation.

Shintani T, et al. (2001 Aug 10). Apg2p functions in autophagosome formation on the perivacuolar structure.

Wang CW, et al. (2001 Aug 10). Apg2 is a novel protein required for the cytoplasm to vacuole targeting, autophagy, and pexophagy pathways.

Barth H, et al. (2001 Aug 22). A genomic screen identifies AUT8 as a novel gene essential for autophagy in the yeast Saccharomyces cerevisiae.

Klionsky DJ, et al. (2003 Oct). A unified nomenclature for yeast autophagy-related genes.

Muthuvijayan V, et al. (2004). In silico reconstruction of nutrient-sensing signal transduction pathways in Aspergillus nidulans.

Reggiori F, et al. (2004 Jan). The Atg1-Atg13 complex regulates Atg9 and Atg23 retrieval transport from the pre-autophagosomal structure.

Martín-Castellanos C, et al. (2005 Nov 22). A large-scale screen in S. pombe identifies seven novel genes required for critical meiotic events.

Suzuki K, et al. (2007 Feb). Hierarchy of Atg proteins in pre-autophagosomal structure organization.

Obara K, et al. (2008 Aug 29). The Atg18-Atg2 complex is recruited to autophagic membranes via phosphatidylinositol 3-phosphate and exerts an essential function.

He C, et al. (2008 Dec). Self-interaction is critical for Atg9 transport and function at the phagophore assembly site during autophagy.

Geng J, et al. (2008 Jul 14). Quantitative analysis of autophagy-related protein stoichiometry by fluorescence microscopy.

Mukaiyama H, et al. (2009 Dec). Autophagy-deficient Schizosaccharomyces pombe mutants undergo partial sporulation during nitrogen starvation.

Sekito T, et al. (2009 May). Atg17 recruits Atg9 to organize the pre-autophagosomal structure.

Kamada Y, et al. (2010 Feb). Tor directly controls the Atg1 kinase complex to regulate autophagy.

van der Vaart A, et al. (2010 Jul 1). Exit from the Golgi is required for the expansion of the autophagosomal phagophore in yeast Saccharomyces cerevisiae.

Mikawa T, et al. (2010 Mar). Fission yeast Vps1 and Atg8 contribute to oxidative stress resistance.

Takeda K, et al. (2011). Identification of genes affecting the toxicity of anti-cancer drug bortezomib by genome-wide screening in S. pombe.

Kobayashi T, et al. (2012 Jul 30). Autophagosome formation can be achieved in the absence of Atg18 by expressing engineered PAS-targeted Atg2.

Watanabe Y, et al. (2012 Sep 14). Structure-based analyses reveal distinct binding sites for Atg2 and phosphoinositides in Atg18.

Sun LL, et al. (2013). Global analysis of fission yeast mating genes reveals new autophagy factors.

Rieter E, et al. (2013 Jan 15). Atg18 function in autophagy is regulated by specific sites within its β-propeller.

Aris JP, et al. (2013 Oct). Autophagy and leucine promote chronological longevity and respiration proficiency during calorie restriction in yeast.

Malecki M, et al. (2016 Nov 25). Functional and regulatory profiling of energy metabolism in fission yeast.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 7 genes with posterior transmembrane prediction > 50%