FOG19181
EOG815F0V

sce:FES1

Genes: 32

SGD Description
Hsp70 (Ssa1p) nucleotide exchange factor; required for the release of misfolded proteins from the Hsp70 system to the Ub-proteasome machinery for destruction; cytosolic homolog of Sil1p, which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum; protein abundance increases in response to DNA replication stress


PomBase Description
Hsp70 nucleotide exchange factor Fes1 (predicted)


AspGD Description
Protein of unknown function


References

Kabani M, et al. (2002 Jul). Nucleotide exchange factor for the yeast Hsp70 molecular chaperone Ssa1p.

Kabani M, et al. (2002 Nov 6). HspBP1, a homologue of the yeast Fes1 and Sls1 proteins, is an Hsc70 nucleotide exchange factor.

Chen D, et al. (2003 Jan). Global transcriptional responses of fission yeast to environmental stress.

Jones G, et al. (2004 May). Propagation of Saccharomyces cerevisiae [PSI+] prion is impaired by factors that regulate Hsp70 substrate binding.

Porat Z, et al. (2005 Dec). Mechanism of polyamine tolerance in yeast: novel regulators and insights.

Shomura Y, et al. (2005 Feb 4). Regulation of Hsp70 function by HspBP1: structural analysis reveals an alternate mechanism for Hsp70 nucleotide exchange.

Aouida M, et al. (2005 Jun 24). AGP2 encodes the major permease for high affinity polyamine import in Saccharomyces cerevisiae.

Ahner A, et al. (2005 Mar 1). Distinct but overlapping functions of Hsp70, Hsp90, and an Hsp70 nucleotide exchange factor during protein biogenesis in yeast.

Dragovic Z, et al. (2006 Dec). Fes1p acts as a nucleotide exchange factor for the ribosome-associated molecular chaperone Ssb1p.

Dragovic Z, et al. (2006 Jun 7). Molecular chaperones of the Hsp110 family act as nucleotide exchange factors of Hsp70s.

Raviol H, et al. (2006 Jun 7). Chaperone network in the yeast cytosol: Hsp110 is revealed as an Hsp70 nucleotide exchange factor.

Wilson-Grady JT, et al. (2008 Mar). Phosphoproteome analysis of fission yeast.

Singh NS, et al. (2011 Dec 6). SIN-inhibitory phosphatase complex promotes Cdc11p dephosphorylation and propagates SIN asymmetry in fission yeast.

Das J, et al. (2013 May 21). Cross-species protein interactome mapping reveals species-specific wiring of stress response pathways.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%