FOG19062
EOG81JWSX

sce:BLM10

Genes: 38

SGD Description
Proteasome activator; binds the core proteasome (CP) and stimulates proteasome-mediated protein degradation by inducing gate opening; required for sequestering CP into proteasome storage granule (PSG) during quiescent phase and for nuclear import of CP in proliferating cells; required for resistance to bleomycin, may be involved in protecting against oxidative damage; similar to mammalian PA200


AspGD Description
Ortholog(s) have peptidase activator activity, proteasome binding activity


References

Febres DE, et al. (2001 Nov). The novel BLM3 gene encodes a protein that protects against lethal effects of oxidative damage.

Robben J, et al. (2002 Jun 15). Revisiting the yeast chromosome VI DNA sequence reveals a correction merging YFL007w and YFL006w to a single ORF.

Kellis M, et al. (2003 May 15). Sequencing and comparison of yeast species to identify genes and regulatory elements.

Fehlker M, et al. (2003 Oct). Blm3 is part of nascent proteasomes and is involved in a late stage of nuclear proteasome assembly.

Doherty K, et al. (2004 Sep). Expression of the expanded YFL007w ORF and assignment of the gene name BLM10.

Schmidt M, et al. (2005 Apr). The HEAT repeat protein Blm10 regulates the yeast proteasome by capping the core particle.

Iwanczyk J, et al. (2006 Oct 27). Structure of the Blm10-20 S proteasome complex by cryo-electron microscopy. Insights into the mechanism of activation of mature yeast proteasomes.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Lehmann A, et al. (2008 Dec). Blm10 binds to pre-activated proteasome core particles with open gate conformation.

Sadre-Bazzaz K, et al. (2010 Mar 12). Structure of a Blm10 complex reveals common mechanisms for proteasome binding and gate opening.

Dange T, et al. (2011 Dec 16). Blm10 protein promotes proteasomal substrate turnover by an active gating mechanism.

Qian MX, et al. (2013 May 23). Acetylation-mediated proteasomal degradation of core histones during DNA repair and spermatogenesis.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 28 genes with posterior transmembrane prediction > 50%