FOG18952
EOG81VHJ8

sce:RRP6

Genes: 32

SGD Description
Nuclear exosome exonuclease component; has 3'-5' exonuclease activity that is regulated by Lrp1p; involved in RNA processing, maturation, surveillance, degradation, tethering, and export; role in sn/snoRNAs precursor degradation; forms a stable heterodimer with Lrp1p; has similarity to E. coli RNase D and to human PM-Sc1 100 (EXOSC10); mutant displays reduced transcription elongation in the G-less-based


PomBase Description
exosome 3'-5' exoribonuclease subunit Rrp6 (predicted)


AspGD Description
Ortholog(s) have 3'-5'-exoribonuclease activity


References

Briggs MW, et al. (1998 May 22). Rrp6p, the yeast homologue of the human PM-Scl 100-kDa autoantigen, is essential for efficient 5.8 S rRNA 3' end formation.

Allmang C, et al. (1999 Aug 15). The yeast exosome and human PM-Scl are related complexes of 3' --> 5' exonucleases.

Burkard KT, et al. (2000 Jan). A nuclear 3'-5' exonuclease involved in mRNA degradation interacts with Poly(A) polymerase and the hnRNA protein Npl3p.

Mitchell P, et al. (2003 Oct). Rrp47p is an exosome-associated protein required for the 3' processing of stable RNAs.

Hieronymus H, et al. (2004 Nov 1). Genome-wide mRNA surveillance is coupled to mRNA export.

Liu Q, et al. (2006 Dec 15). Reconstitution, activities, and structure of the eukaryotic RNA exosome.

Dziembowski A, et al. (2007 Jan). A single subunit, Dis3, is essentially responsible for yeast exosome core activity.

Granato DC, et al. (2008 Aug). Nop53p interacts with 5.8S rRNA co-transcriptionally, and regulates processing of pre-rRNA by the exosome.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%