FOG18945
EOG81VHK8

sce:NFS1

Genes: 33

SGD Description
Cysteine desulfurase; involved in iron-sulfur cluster (Fe/S) biogenesis and in thio-modification of mitochondrial and cytoplasmic tRNAs; essential protein located predominantly in mitochondria


PomBase Description
mitochondrial cysteine desulfurase Nfs1 (predicted)


AspGD Description
Ortholog(s) have cysteine desulfurase activity and role in cellular iron ion homeostasis, iron-sulfur cluster assembly, mitochondrial tRNA thio-modification, tRNA wobble uridine modification


References

Froman BE, et al. (1984 Nov). Nucleotide sequence of the 3' terminal region of the LEU2 gene from Saccharomyces cerevisiae.

Kolman C, et al. (1993 Mar). SPL1-1, a Saccharomyces cerevisiae mutation affecting tRNA splicing.

Plant EP, et al. (1998 Feb). The SPL1 tRNA splicing gene of Candida maltosa and Candida albicans.

Kispal G, et al. (1999 Jul 15). The mitochondrial proteins Atm1p and Nfs1p are essential for biogenesis of cytosolic Fe/S proteins.

Li J, et al. (1999 Nov 12). Yeast mitochondrial protein, Nfs1p, coordinately regulates iron-sulfur cluster proteins, cellular iron uptake, and iron distribution.

Mühlenhoff U, et al. (2004 Aug 27). Functional characterization of the eukaryotic cysteine desulfurase Nfs1p from Saccharomyces cerevisiae.

Nakai Y, et al. (2004 Mar 26). Yeast Nfs1p is involved in thio-modification of both mitochondrial and cytoplasmic tRNAs.

Lan CY, et al. (2004 Sep). Regulatory networks affected by iron availability in Candida albicans.

Chibana H, et al. (2005 Aug). Sequence finishing and gene mapping for Candida albicans chromosome 7 and syntenic analysis against the Saccharomyces cerevisiae genome.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%