FOG18884
EOG82280P

sce:SSK1

Genes: 34

SGD Description
Cytoplasmic phosphorelay intermediate osmosensor and regulator; part of a two-component signal transducer that mediates osmosensing via a phosphorelay mechanism; required for mitophagy; dephosphorylated form is degraded by the ubiquitin-proteasome system; potential Cdc28p substrate


PomBase Description
response regulator Mcs4


AspGD Description
Ortholog(s) have MAP kinase activity, phosphorelay response regulator activity


References

Maeda T, et al. (1994 May 19). A two-component system that regulates an osmosensing MAP kinase cascade in yeast.

Posas F, et al. (1996 Sep 20). Yeast HOG1 MAP kinase cascade is regulated by a multistep phosphorelay mechanism in the SLN1-YPD1-SSK1 "two-component" osmosensor.

Calera JA, et al. (1999). Histidine kinase, two-component signal transduction proteins of Candida albicans and the pathogenesis of candidosis.

Calera JA, et al. (1999 Sep 15). Identification of a putative response regulator two-component phosphorelay gene ( CaSSK1) from Candida albicans.

Janiak-Spens F, et al. (2000 Dec). Novel role for an HPt domain in stabilizing the phosphorylated state of a response regulator domain.

Calera JA, et al. (2000 Feb). Defective hyphal development and avirulence caused by a deletion of the SSK1 response regulator gene in Candida albicans.

Li D, et al. (2002 Mar). Temporal expression of the Candida albicans genes CHK1 and CSSK1, adherence, and morphogenesis in a model of reconstituted human esophageal epithelial candidiasis.

Lu JM, et al. (2003 Dec). Saccharomyces cerevisiae histidine phosphotransferase Ypd1p shuttles between the nucleus and cytoplasm for SLN1-dependent phosphorylation of Ssk1p and Skn7p.

Sato N, et al. (2003 Sep). Phosphorelay-regulated degradation of the yeast Ssk1p response regulator by the ubiquitin-proteasome system.

Li D, et al. (2004 Oct). Studies on the regulation of the two-component histidine kinase gene CHK1 in Candida albicans using the heterologous lacZ reporter gene.

Du C, et al. (2005 Feb). Deletion of the SSK1 response regulator gene in Candida albicans contributes to enhanced killing by human polymorphonuclear neutrophils.

Furukawa K, et al. (2005 Jun). Aspergillus nidulans HOG pathway is activated only by two-component signalling pathway in response to osmotic stress.

Gruhler A, et al. (2005 Mar). Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway.

Menon V, et al. (2006 Nov). Functional studies of the Ssk1p response regulator protein of Candida albicans as determined by phenotypic analysis of receiver domain point mutants.

Hagiwara D, et al. (2007 Apr). The SskA and SrrA response regulators are implicated in oxidative stress responses of hyphae and asexual spores in the phosphorelay signaling network of Aspergillus nidulans.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Asano Y, et al. (2007 Jul). Characterization of the bZip-type transcription factor NapA with reference to oxidative stress response in Aspergillus nidulans.

Hagiwara D, et al. (2007 Mar). Characterization of the NikA histidine kinase implicated in the phosphorelay signal transduction of Aspergillus nidulans, with special reference to fungicide responses.

Azuma N, et al. (2007 Oct). In vitro analysis of His-Asp phosphorelays in Aspergillus nidulans: the first direct biochemical evidence for the existence of His-Asp phosphotransfer systems in filamentous fungi.

Chauhan N, et al. (2007 Oct). The Ssk1p response regulator and Chk1p histidine kinase mutants of Candida albicans are hypersensitive to fluconazole and voriconazole.

Vargas-Pérez I, et al. (2007 Sep). Response regulators SrrA and SskA are central components of a phosphorelay system involved in stress signal transduction and asexual sporulation in Aspergillus nidulans.

Menon V, et al. (2008 Aug). Transcriptional profiling of the Candida albicans Ssk1p receiver domain point mutants and their virulence.

Hagiwara D, et al. (2008 Oct). Characterization of bZip-type transcription factor AtfA with reference to stress responses of conidia of Aspergillus nidulans.

Hagiwara D, et al. (2009 Jul). Characterization of NikA histidine kinase and two response regulators with special reference to osmotic adaptation and asexual development in Aspergillus nidulans.

Miskei M, et al. (2009 Mar). Annotation of stress-response proteins in the aspergilli.

Hagiwara D, et al. (2009 Nov). Transcriptional profiling for Aspergillusnidulans HogA MAPK signaling pathway in response to fludioxonil and osmotic stress.

Colabardini AC, et al. (2010 Dec). Involvement of the Aspergillus nidulans protein kinase C with farnesol tolerance is related to the unfolded protein response.

Lara-Rojas F, et al. (2011 Apr). Aspergillus nidulans transcription factor AtfA interacts with the MAPK SakA to regulate general stress responses, development and spore functions.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Eigentler A, et al. (2012 Jun). The anisin1 gene encodes a defensin-like protein and supports the fitness of Aspergillus nidulans.

Ma D, et al. (2013 Feb). Current understanding of HOG-MAPK pathway in Aspergillus fumigatus.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%