FOG18819
EOG8254BK

sce:MAD2

Genes: 30

SGD Description
Component of the spindle-assembly checkpoint complex; delays onset of anaphase in cells with defects in mitotic spindle assembly; forms a complex with Mad1p; regulates APC/C activity during prometaphase and metaphase of meiosis I; gene dosage imbalance between MAD1 and MAD2 leads to chromosome instability


PomBase Description
mitotic spindle checkpoint protein Mad2


AspGD Description
Ortholog(s) have anaphase-promoting complex binding activity and role in chromosome decondensation, mitotic DNA integrity checkpoint, mitotic cell cycle checkpoint inhibiting CAR assembly, mitotic spindle assembly checkpoint


References

Li R, et al. (1991 Aug 9). Feedback control of mitosis in budding yeast.

Li R, et al. (1993 Nov 4). The mitotic feedback control gene MAD2 encodes the alpha-subunit of a prenyltransferase.

Hwang LH, et al. (1998 Feb 13). Budding yeast Cdc20: a target of the spindle checkpoint.

Chen RH, et al. (1999 Aug). The spindle checkpoint of budding yeast depends on a tight complex between the Mad1 and Mad2 proteins.

Fraschini R, et al. (2001 Dec 3). Bub3 interaction with Mad2, Mad3 and Cdc20 is mediated by WD40 repeats and does not require intact kinetochores.

Bai C, et al. (2002 Jul). Spindle assembly checkpoint component CaMad2p is indispensable for Candida albicans survival and virulence in mice.

Lou Y, et al. (2004 May 7). NEK2A interacts with MAD1 and possibly functions as a novel integrator of the spindle checkpoint signaling.

Poddar A, et al. (2005 May). Two complexes of spindle checkpoint proteins containing Cdc20 and Mad2 assemble during mitosis independently of the kinetochore in Saccharomyces cerevisiae.

De Souza CP, et al. (2009 Apr). Mlp1 acts as a mitotic scaffold to spatially regulate spindle assembly checkpoint proteins in Aspergillus nidulans.

De Souza CP, et al. (2011 Jun 3). Regulated inactivation of the spindle assembly checkpoint without functional mitotic spindles.

Thakur J, et al. (2011 Oct). The essentiality of the fungus-specific Dam1 complex is correlated with a one-kinetochore-one-microtubule interaction present throughout the cell cycle, independent of the nature of a centromere.

Hu K, et al. (2012 Jun). Shp1, a regulator of protein phosphatase 1 Glc7, has important roles in cell morphogenesis, cell cycle progression and DNA damage response in Candida albicans.

Edgerton H, et al. (2015 Feb). Spatial regulation of the spindle assembly checkpoint and anaphase-promoting complex in Aspergillus nidulans.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%