FOG18800
EOG8280GJ

sce:LOS1

Genes: 34

SGD Description
Nuclear pore protein; involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm


PomBase Description
karyopherin exportin T Los1 (predicted)


AspGD Description
Ortholog(s) have cytosol, nuclear envelope localization


References

Hopper AK, et al. (1980 Mar). Processing of intervening sequences: a new yeast mutant which fails to excise intervening sequences from precursor tRNAs.

Hurt DJ, et al. (1987 Mar). Cloning and characterization of LOS1, a Saccharomyces cerevisiae gene that affects tRNA splicing.

Shen WC, et al. (1993 Sep 15). The Saccharomyces cerevisiae LOS1 gene involved in pre-tRNA splicing encodes a nuclear protein that behaves as a component of the nuclear matrix.

Shen WC, et al. (1996 Jun). Los1p, involved in yeast pre-tRNA splicing, positively regulates members of the SOL gene family.

Simos G, et al. (1996 May 1). Nuclear pore proteins are involved in the biogenesis of functional tRNA.

Hellmuth K, et al. (1998 Nov). Yeast Los1p has properties of an exportin-like nucleocytoplasmic transport factor for tRNA.

Sarkar S, et al. (1998 Nov). tRNA nuclear export in saccharomyces cerevisiae: in situ hybridization analysis.

Hurt E, et al. (1999 Feb 8). A novel in vivo assay reveals inhibition of ribosomal nuclear export in ran-cycle and nucleoporin mutants.

Qiu H, et al. (2000 Apr). Defects in tRNA processing and nuclear export induce GCN4 translation independently of phosphorylation of the alpha subunit of eukaryotic translation initiation factor 2.

Cleary JD, et al. (2000 Apr 1). Nucleotides of the tRNA D-stem that play an important role in nuclear-tRNA export in Saccharomyces cerevisiae.

Grosshans H, et al. (2000 Apr 1). An aminoacylation-dependent nuclear tRNA export pathway in yeast.

Steiner-Mosonyi M, et al. (2004 Mar 15). The nuclear tRNA aminoacylation-dependent pathway may be the principal route used to export tRNA from the nucleus in Saccharomyces cerevisiae.

Chibana H, et al. (2005 Aug). Sequence finishing and gene mapping for Candida albicans chromosome 7 and syntenic analysis against the Saccharomyces cerevisiae genome.

Shaheen HH, et al. (2005 Aug 9). Retrograde movement of tRNAs from the cytoplasm to the nucleus in Saccharomyces cerevisiae.

Takano A, et al. (2005 Jul 1). tRNA actively shuttles between the nucleus and cytosol in yeast.

McGuire AT, et al. (2007 Jan 24). Cex1p is a novel cytoplasmic component of the Saccharomyces cerevisiae nuclear tRNA export machinery.

Quan X, et al. (2007 Jul). The localization of nuclear exporters of the importin-beta family is regulated by Snf1 kinase, nutrient supply and stress.

Ghavidel A, et al. (2007 Nov 30). Impaired tRNA nuclear export links DNA damage and cell-cycle checkpoint.

Strub BR, et al. (2007 Oct). Utp8p is a nucleolar tRNA-binding protein that forms a complex with components of the nuclear tRNA export machinery in Saccharomyces cerevisiae.

Murphy D, et al. (2008 Mar 25). The evolution of core proteins involved in microRNA biogenesis.

Takeda K, et al. (2011). Identification of genes affecting the toxicity of anti-cancer drug bortezomib by genome-wide screening in S. pombe.

Stewart EV, et al. (2011 Apr 22). Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.

Markina-Iñarrairaegui A, et al. (2011 Oct). Nuclear transporters in a multinucleated organism: functional and localization analyses in Aspergillus nidulans.

Cherkasova V, et al. (2012 Feb). Altered nuclear tRNA metabolism in La-deleted Schizosaccharomyces pombe is accompanied by a nutritional stress response involving Atf1p and Pcr1p that is suppressible by Xpo-t/Los1p.

Pan X, et al. (2012 Nov 23). Identification of novel genes involved in DNA damage response by screening a genome-wide Schizosaccharomyces pombe deletion library.

Chen Z, et al. (2012 Oct). A genetic screen to discover pathways affecting cohesin function in Schizosaccharomyces pombe identifies chromatin effectors.

Anver S, et al. (2014 Aug). Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Doi A, et al. (2015 Apr). Chemical genomics approach to identify genes associated with sensitivity to rapamycin in the fission yeast Schizosaccharomyces pombe.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 17 genes with posterior transmembrane prediction > 50%