FOG18765
EOG82BVQJ

sce:PEP5

Genes: 33

SGD Description
Histone E3 ligase, component of CORVET membrane tethering complex; peripheral vacuolar membrane protein required for protein trafficking and vacuole biogenesis; interacts with Pep7p; involved in ubiquitylation and degradation of excess histones


PomBase Description
HOPs/CORVET complex biquitin protein ligase E3 subunit Vps11 (predicted)


AspGD Description
Ortholog(s) have phosphatidylinositol binding, ubiquitin-protein transferase activity


References

Jones EW, et al. (1977 Jan). Proteinase mutants of Saccharomyces cerevisiae.

Chvatchko Y, et al. (1986 Aug 1). Two yeast mutants defective in endocytosis are defective in pheromone response.

Robinson JS, et al. (1988 Nov). Protein sorting in Saccharomyces cerevisiae: isolation of mutants defective in the delivery and processing of multiple vacuolar hydrolases.

Rothman JH, et al. (1989 Jul). Characterization of genes required for protein sorting and vacuolar function in the yeast Saccharomyces cerevisiae.

Dulić V, et al. (1989 May). Characterization of the END1 gene required for vacuole biogenesis and gluconeogenic growth of budding yeast.

Woolford CA, et al. (1990 Aug). Isolation and characterization of PEP5, a gene essential for vacuolar biogenesis in Saccharomyces cerevisiae.

Wada Y, et al. (1992 Sep 15). Genes for directing vacuolar morphogenesis in Saccharomyces cerevisiae. I. Isolation and characterization of two classes of vam mutants.

Seals DF, et al. (2000 Aug 15). A Ypt/Rab effector complex containing the Sec1 homolog Vps33p is required for homotypic vacuole fusion.

Srivastava A, et al. (2000 Sep). Pep3p/Pep5p complex: a putative docking factor at multiple steps of vesicular transport to the vacuole of Saccharomyces cerevisiae.

Stroupe C, et al. (2006 Apr 19). Purification of active HOPS complex reveals its affinities for phosphoinositides and the SNARE Vam7p.

Peplowska K, et al. (2007 May). The CORVET tethering complex interacts with the yeast Rab5 homolog Vps21 and is involved in endo-lysosomal biogenesis.

Sajiki K, et al. (2009 May 1). Genetic control of cellular quiescence in S. pombe.

Singh RK, et al. (2012). Novel E3 ubiquitin ligases that regulate histone protein levels in the budding yeast Saccharomyces cerevisiae.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%