FOG18714
EOG82FR0C

sce:MSS51

Genes: 33

SGD Description
Specific translational activator for the mitochondrial COX1 mRNA; loosely associated with the matrix face of the mitochondrial inner membrane; localizes to vacuole membrane in response to H2O2; influences both COX1 mRNA translation and Cox1p assembly into cytochrome c oxidase; binds to heme B, which may be a mechanism for sensing oxygen levels in order to regulate cytochrome c oxidase biogenesis


PomBase Description
mitochondrial splicing suppressor Mss51 (predicted)


AspGD Description
Ortholog(s) have translation regulator activity and role in mitochondrial respiratory chain complex IV biogenesis, positive regulation of mitochondrial translation


References

Faye G, et al. (1983 Jan). Analysis of a yeast nuclear gene involved in the maturation of mitochondrial pre-messenger RNA of the cytochrome oxidase subunit I.

Simon M, et al. (1984 Jan). Steps in processing of the mitochondrial cytochrome oxidase subunit I pre-mRNA affected by a nuclear mutation in yeast.

Decoster E, et al. (1990 Oct). The MSS51 gene product is required for the translation of the COX1 mRNA in yeast mitochondria.

Simon M, et al. (1992 Jul). Analysis of the MSS51 region on chromosome XII of Saccharomyces cerevisiae.

Siep M, et al. (2000 Apr). Mss51p, a putative translational activator of cytochrome c oxidase subunit-1 (COX1) mRNA, is required for synthesis of Cox1p in Saccharomyces cerevisiae.

Barrientos A, et al. (2002 Jan 15). Shy1p is necessary for full expression of mitochondrial COX1 in the yeast model of Leigh's syndrome.

Sickmann A, et al. (2003 Nov 11). The proteome of Saccharomyces cerevisiae mitochondria.

Perez-Martinez X, et al. (2003 Nov 3). Mss51p promotes mitochondrial Cox1p synthesis and interacts with newly synthesized Cox1p.

Barrientos A, et al. (2004 Sep 1). Mss51p and Cox14p jointly regulate mitochondrial Cox1p expression in Saccharomyces cerevisiae.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%