FOG18659
EOG82JM7V

sce:SUB2

Genes: 34

SGD Description
Component of the TREX complex required for nuclear mRNA export; member of the DEAD-box RNA helicase superfamily and is involved in early and late steps of spliceosome assembly; homolog of the human splicing factor hUAP56; relocalizes from nucleus to cytoplasm upon DNA replication stress


PomBase Description
TREX complex subunit, ATP-dependent RNA helicase Uap56


AspGD Description
Ortholog(s) have ATP-dependent RNA helicase activity


References

Shiratori A, et al. (1999 Feb). Systematic identification, classification, and characterization of the open reading frames which encode novel helicase-related proteins in Saccharomyces cerevisiae by gene disruption and Northern analysis.

Fan HY, et al. (2001 Aug). High-copy-number expression of Sub2p, a member of the RNA helicase superfamily, suppresses hpr1-mediated genomic instability.

Kistler AL, et al. (2001 Jan 1). Deletion of MUD2, the yeast homolog of U2AF65, can bypass the requirement for sub2, an essential spliceosomal ATPase.

Libri D, et al. (2001 Jan 1). Multiple roles for the yeast SUB2/yUAP56 gene in splicing.

Zhang M, et al. (2001 Jan 1). Identification and characterization of yUAP/Sub2p, a yeast homolog of the essential human pre-mRNA splicing factor hUAP56.

Strässer K, et al. (2001 Oct 11). Splicing factor Sub2p is required for nuclear mRNA export through its interaction with Yra1p.

Jensen TH, et al. (2001 Oct 30). The DECD box putative ATPase Sub2p is an early mRNA export factor.

West RW Jr, et al. (2002 Apr 17). DEAD-box RNA helicase Sub2 is required for expression of lacZ fusions in Saccharomyces cerevisiae and is a dosage-dependent suppressor of RLR1 (THO2).

Zenklusen D, et al. (2002 Dec). Stable mRNP formation and export require cotranscriptional recruitment of the mRNA export factors Yra1p and Sub2p by Hpr1p.

Jimeno S, et al. (2002 Jul 1). The yeast THO complex and mRNA export factors link RNA metabolism with transcription and genome instability.

Strässer K, et al. (2002 May 16). TREX is a conserved complex coupling transcription with messenger RNA export.

Fischer T, et al. (2002 Nov 1). The mRNA export machinery requires the novel Sac3p-Thp1p complex to dock at the nucleoplasmic entrance of the nuclear pores.

Rondón AG, et al. (2003 Oct 3). Molecular evidence that the eukaryotic THO/TREX complex is required for efficient transcription elongation.

Gruhler A, et al. (2005 Mar). Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway.

Lahue E, et al. (2005 May). The Saccharomyces cerevisiae Sub2 protein suppresses heterochromatic silencing at telomeres and subtelomeric genes.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%