FOG18526
EOG82V6ZG

sce:MTM1

Genes: 33

SGD Description
Mitochondrial protein of the mitochondrial carrier family; high affinity pyridoxal 5'-phosphate (PLP) transporter, important for delivery of PLP cofactor to mitochondrial enzymes; involved in mitochondrial iron homeostasis and in activating mitochondrial Sod2p by facilitating insertion of an essential manganese cofactor


PomBase Description
mitochondrial manganese ion transmembrane transporter Mtm1 (predicted)


AspGD Description
Ortholog(s) have metallochaperone activity, pyridoxal phosphate binding activity, role in manganese ion transport, pyridoxal phosphate transport and mitochondrion localization


References

Luk E, et al. (2003 Sep 2). Manganese activation of superoxide dismutase 2 in Saccharomyces cerevisiae requires MTM1, a member of the mitochondrial carrier family.

Yang M, et al. (2006 Apr 19). The effects of mitochondrial iron homeostasis on cofactor specificity of superoxide dismutase 2.

Kumánovics A, et al. (2008 Apr 18). Identification of FRA1 and FRA2 as genes involved in regulating the yeast iron regulon in response to decreased mitochondrial iron-sulfur cluster synthesis.

Lee YL, et al. (2008 Sep 30). Transcriptional response according to strength of calorie restriction in Saccharomyces cerevisiae.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 31 genes with posterior transmembrane prediction > 50%