FOG18412
EOG834TNP

sce:BRE2

Genes: 33

SGD Description
Subunit of COMPASS (Set1C) complex; COMPASS methylates Lys4 of histone H3 and functions in silencing at telomeres; has a C-terminal Sdc1 Dpy-30 Interaction (SDI) domain that mediates binding to Sdc1p; similar to trithorax-group protein ASH2L


PomBase Description
Ash2-trithorax family protein


AspGD Description
Ortholog(s) have histone methyltransferase activity (H3-K4 specific) activity


References

Levin DE, et al. (1994 Nov 1). Evidence against the existence of the purported Saccharomyces cerevisiae PKC2 gene.

Roguev A, et al. (2001 Dec 17). The Saccharomyces cerevisiae Set1 complex includes an Ash2 homologue and methylates histone 3 lysine 4.

Miller T, et al. (2001 Nov 6). COMPASS: a complex of proteins associated with a trithorax-related SET domain protein.

Krogan NJ, et al. (2002 Mar 29). COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expression.

Bok JW, et al. (2009 Jul). Chromatin-level regulation of biosynthetic gene clusters.

Chiang YM, et al. (2010 Apr). Characterization of the Aspergillus nidulans monodictyphenone gene cluster.

Brakhage AA, et al. (2011 Jan). Fungal secondary metabolites - strategies to activate silent gene clusters.

Sanchez JF, et al. (2011 Mar 23). Genome-based deletion analysis reveals the prenyl xanthone biosynthesis pathway in Aspergillus nidulans.

Palmer JM, et al. (2013). Loss of CclA, required for histone 3 lysine 4 methylation, decreases growth but increases secondary metabolite production in Aspergillus fumigatus.

Harting R, et al. (2013 Dec). Interplay of the fungal sumoylation network for control of multicellular development.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%