FOG18408
EOG834TP7

sce:MRE11

Genes: 32

SGD Description
Nuclease subunit of the MRX complex with Rad50p and Xrs2p; complex functions in repair of DNA double-strand breaks and in telomere stability; Mre11p associates with Ser/Thr-rich ORFs in premeiotic phase; nuclease activity required for MRX function; widely conserved; forms nuclear foci upon DNA replication stress


PomBase Description
Mre11 nuclease


AspGD Description
Ortholog(s) have manganese ion binding, nuclease activity


References

Ogawa H, et al. (1995). Functions of the yeast meiotic recombination genes, MRE11 and MRE2.

Johzuka K, et al. (1995 Apr). Interaction of Mre11 and Rad50: two proteins required for DNA repair and meiosis-specific double-strand break formation in Saccharomyces cerevisiae.

Paull TT, et al. (1998 Jun). The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%