FOG18400
EOG834TPP

sce:GLE1

Genes: 29

SGD Description
Cytoplasmic nucleoporin required for polyadenylated mRNA export; contains a nuclear export signal; when bound to inositol hexakisphosphate (IP6), functions as an activator for the Dbp5p ATPase activity at the nuclear pore complex during mRNA export; mediates translation initiation; required for efficient translation termination


PomBase Description
RNA export factor, cytoplasmic nucleoporin Gle1


References

Murphy R, et al. (1996 Sep 26). An RNA-export mediator with an essential nuclear export signal.

Hodge CA, et al. (1999 Oct 15). Rat8p/Dbp5p is a shuttling transport factor that interacts with Rat7p/Nup159p and Gle1p and suppresses the mRNA export defect of xpo1-1 cells.

Strahm Y, et al. (1999 Oct 15). The RNA export factor Gle1p is located on the cytoplasmic fibrils of the NPC and physically interacts with the FG-nucleoporin Rip1p, the DEAD-box protein Rat8p/Dbp5p and a new protein Ymr 255p.

Rout MP, et al. (2000 Feb 21). The yeast nuclear pore complex: composition, architecture, and transport mechanism.

Jensen TH, et al. (2001 Apr). A block to mRNA nuclear export in S. cerevisiae leads to hyperadenylation of transcripts that accumulate at the site of transcription.

Suntharalingam M, et al. (2003 Jun). Peering through the pore: nuclear pore complex structure, assembly, and function.

Suntharalingam M, et al. (2004 Aug 20). Nuclear export of the yeast mRNA-binding protein Nab2 is linked to a direct interaction with Gfd1 and to Gle1 function.

Yuasa T, et al. (2004 Nov). An interactive gene network for securin-separase, condensin, cohesin, Dis1/Mtc1 and histones constructed by mass transformation.

Moon D, et al. (2008 Aug). The fission yeast homologue of Glel is essential for growth and involved in mRNA export.

Asakawa H, et al. (2010 Nov 9). Virtual breakdown of the nuclear envelope in fission yeast meiosis.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Das J, et al. (2013 May 21). Cross-species protein interactome mapping reveals species-specific wiring of stress response pathways.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 6 genes with posterior transmembrane prediction > 50%