FOG18368
EOG837PW4

sce:RNA14

Genes: 33

SGD Description
Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; bridges interaction between Rna15p and Hrp1p in the CF I complex; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; required for gene looping and maintenance of genome stability; relocalizes to the cytosol in response to hypoxia


PomBase Description
mRNA cleavage and polyadenylation specificity factor complex subunit Rna14 (predicted)


AspGD Description
Ortholog(s) have nucleus localization


References

Minvielle-Sebastia L, et al. (1991 Jun). Mutations in the yeast RNA14 and RNA15 genes result in an abnormal mRNA decay rate; sequence analysis reveals an RNA-binding domain in the RNA15 protein.

Minvielle-Sebastia L, et al. (1994 Dec 9). RNA14 and RNA15 proteins as components of a yeast pre-mRNA 3'-end processing factor.

Kessler MM, et al. (1996 Oct 25). Purification of the Saccharomyces cerevisiae cleavage/polyadenylation factor I. Separation into two components that are required for both cleavage and polyadenylation of mRNA 3' ends.

Minvielle-Sebastia L, et al. (1997 Jul 22). The major yeast poly(A)-binding protein is associated with cleavage factor IA and functions in premessenger RNA 3'-end formation.

Ohnacker M, et al. (2000 Jan 4). The WD-repeat protein pfs2p bridges two essential factors within the yeast pre-mRNA 3'-end-processing complex.

Gross S, et al. (2001 May 22). Five subunits are required for reconstitution of the cleavage and polyadenylation activities of Saccharomyces cerevisiae cleavage factor I.

Sadowski M, et al. (2003 May 1). Independent functions of yeast Pcf11p in pre-mRNA 3' end processing and in transcription termination.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Sonkar A, et al. (2016 Feb). Cleavage and polyadenylation factor, Rna14 is an essential protein required for the maintenance of genomic integrity in fission yeast Schizosaccharomyces pombe.

Yadav S, et al. (2016 Jun). Mutant allele of rna14 in fission yeast affects pre-mRNA splicing.

Wittmann S, et al. (2017 Apr 3). The conserved protein Seb1 drives transcription termination by binding RNA polymerase II and nascent RNA.

Sonkar A, et al. (2017 May 31). Fission yeast Ctf1, a cleavage and polyadenylation factor subunit is required for the maintenance of genomic integrity.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 3 genes with posterior transmembrane prediction > 50%