FOG18329
EOG83BK3X

sce:TIF4631;TIF4632

Genes: 38

SGD Description
Translation initiation factor eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); interacts with Pab1p and with eIF4A (Tif1p); also has a role in biogenesis of the large ribosomal subunit; TIF4631 has a paralog, TIF4632, that arose from the whole genome duplication|Translation initiation factor eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); associates with the poly(A)-binding protein Pab1p, also interacts with eIF4A (Tif1p); TIF4632 has a paralog, TIF4631, that arose from the whole genome duplication


PomBase Description
translation initiation factor eIF4G


References

Goyer C, et al. (1993 Aug). TIF4631 and TIF4632: two yeast genes encoding the high-molecular-weight subunits of the cap-binding protein complex (eukaryotic initiation factor 4F) contain an RNA recognition motif-like sequence and carry out an essential function.

Tarun SZ Jr, et al. (1996 Dec 16). Association of the yeast poly(A) tail binding protein with translation initiation factor eIF-4G.

Tarun SZ Jr, et al. (1997 Aug 19). Translation initiation factor eIF4G mediates in vitro poly(A) tail-dependent translation.

Feuermann M, et al. (1997 Jul). The characterization of two new clusters of duplicated genes suggests a 'Lego' organization of the yeast Saccharomyces cerevisiae chromosomes.

Kessler SH, et al. (1998 Jan). RNA recognition motif 2 of yeast Pab1p is required for its functional interaction with eukaryotic translation initiation factor 4G.

Wells SE, et al. (1998 Jul). Circularization of mRNA by eukaryotic translation initiation factors.

Otero LJ, et al. (1999 Jun 1). The yeast poly(A)-binding protein Pab1p stimulates in vitro poly(A)-dependent and cap-dependent translation by distinct mechanisms.

Vilela C, et al. (2000 Aug 15). The eukaryotic mRNA decapping protein Dcp1 interacts physically and functionally with the eIF4F translation initiation complex.

Tharun S, et al. (2001 Nov). Targeting an mRNA for decapping: displacement of translation factors and association of the Lsm1p-7p complex on deadenylated yeast mRNAs.

Gross JD, et al. (2003 Dec 12). Ribosome loading onto the mRNA cap is driven by conformational coupling between eIF4G and eIF4E.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 4 genes with posterior transmembrane prediction > 50%