FOG18286
EOG83FFCG

sce:YME1

Genes: 37

SGD Description
Catalytic subunit of i-AAA protease complex; complex is located in mitochondrial inner membrane; responsible for degradation of unfolded or misfolded mitochondrial gene products; serves as nonconventional translocation motor to pull PNPase into intermembrane space; also has role in intermembrane space protein folding; mutation causes elevated rate of mitochondrial turnover; human homolog YME1L1 complements yeast null mutant


PomBase Description
mitochondrial inner membrane i-AAA protease complex subunit Yme1 (predicted)


AspGD Description
Ortholog(s) have ATP-dependent peptidase activity


References

Thorsness PE, et al. (1993 Sep). Inactivation of YME1, a member of the ftsH-SEC18-PAS1-CDC48 family of putative ATPase-encoding genes, causes increased escape of DNA from mitochondria in Saccharomyces cerevisiae.

Schnall R, et al. (1994 Sep). Identification of a set of yeast genes coding for a novel family of putative ATPases with high similarity to constituents of the 26S protease complex.

Nakai T, et al. (1995 Aug). Multiple genes, including a member of the AAA family, are essential for degradation of unassembled subunit 2 of cytochrome c oxidase in yeast mitochondria.

Weber ER, et al. (1996 Feb). Biochemical and functional analysis of the YME1 gene product, an ATP and zinc-dependent mitochondrial protease from S. cerevisiae.

Dunn CD, et al. (2006 Jan). A genomewide screen for petite-negative yeast strains yields a new subunit of the i-AAA protease complex.

Graef M, et al. (2006 Oct). Substrate specific consequences of central pore mutations in the i-AAA protease Yme1 on substrate engagement.

Dunn CD, et al. (2008 Dec). Mgr3p and Mgr1p are adaptors for the mitochondrial i-AAA protease complex.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 22 genes with posterior transmembrane prediction > 50%