FOG18271
EOG83FFFR

sce:RFA2

Genes: 32

SGD Description
Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination; RPA protects against inappropriate telomere recombination, and upon telomere uncapping, prevents cell proliferation by a checkpoint-independent pathway; in concert with Sgs1p-Top2p-Rmi1p, stimulates DNA catenation/decatenation activity of Top3p; protein abundance increases in response to DNA replication s


PomBase Description
single-stranded DNA binding protein Ssb2


AspGD Description
Ortholog(s) have single-stranded DNA binding activity and DNA replication factor A complex, cytosol, site of double-strand break localization


References

Din S, et al. (1990 Jun). Cell-cycle-regulated phosphorylation of DNA replication factor A from human and yeast cells.

Brill SJ, et al. (1991 Sep). Replication factor-A from Saccharomyces cerevisiae is encoded by three essential genes coordinately expressed at S phase.

Luche RM, et al. (1993 Sep). Saccharomyces cerevisiae BUF protein binds to sequences participating in DNA replication in addition to those mediating transcriptional repression (URS1) and activation.

Ishiai M, et al. (1996 Aug 23). Purification, gene cloning, and reconstitution of the heterotrimeric single-stranded DNA-binding protein from Schizosaccharomyces pombe.

Goldman GH, et al. (2004 Apr). Aspergillus nidulans as a model system to characterize the DNA damage response in eukaryotes.

Ricke RM, et al. (2004 Oct 22). Mcm10 regulates the stability and chromatin association of DNA polymerase-alpha.

Gruhler A, et al. (2005 Mar). Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Nitani N, et al. (2008 Sep 2). Mcm4 C-terminal domain of MCM helicase prevents excessive formation of single-stranded DNA at stalled replication forks.

Saito Y, et al. (2013). The proteasome factor Bag101 binds to Rad22 and suppresses homologous recombination.

Yu Y, et al. (2013 Jun 1). A proteome-wide visual screen identifies fission yeast proteins localizing to DNA double-strand breaks.

Wang J, et al. (2013 Sep 1). Epe1 recruits BET family bromodomain protein Bdf2 to establish heterochromatin boundaries.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

McDonald KR, et al. (2016 Sep). Pfh1 Is an Accessory Replicative Helicase that Interacts with the Replisome to Facilitate Fork Progression and Preserve Genome Integrity.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%