FOG18229
EOG83J9QB

sce:SIR4

Genes: 6

SGD Description
SIR protein involved in assembly of silent chromatin domains; silent information regulator (SIR) along with SIR2 and SIR3; involved in assembly of silent chromatin domains at telomeres and the silent mating-type loci; potentially phosphorylated by Cdc28p; some alleles of SIR4 prolong lifespan


References

Marshall M, et al. (1987 Dec). Functional domains of SIR4, a gene required for position effect regulation in Saccharomyces cerevisiae.

Davies CJ, et al. (1995 Feb 11). Insertion site specificity of the transposon Tn3.

Zhang Z, et al. (1997 Sep). Identification of a member of a DNA-dependent ATPase family that causes interference with silencing.

Gasser SM, et al. (2001 Nov 14). The molecular biology of the SIR proteins.

Chang JF, et al. (2003 Jun). Structure of the coiled-coil dimerization motif of Sir4 and its interaction with Sir3.

Roy R, et al. (2004 Jan 2). Separation-of-function mutants of yeast Ku80 reveal a Yku80p-Sir4p interaction involved in telomeric silencing.

Denison C, et al. (2005 Mar). A proteomic strategy for gaining insights into protein sumoylation in yeast.

Bupp JM, et al. (2007 Dec 3). Telomere anchoring at the nuclear periphery requires the budding yeast Sad1-UNC-84 domain protein Mps3.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%