FOG18205
EOG83N5X1

sce:CCZ1

Genes: 5

SGD Description
Subunit of a heterodimeric guanine nucleotide exchange factor (GEF); subunit of the Mon1-Ccz1 GEF complex, which stimulates nucleotide exchange and activation of Ypt7p, a Rab family GTPase involved in membrane tethering and fusion events at the late endosome and vacuole; GEF activity is stimulated by membrane association and anionic phospholipids; involved in localizing Ypt7p to the vacuolar membrane; required for macroautophagy, the CVT pathway and mitophagy


References

Kucharczyk R, et al. (1999 Jul). Disruption of six novel yeast genes located on chromosome II reveals one gene essential for vegetative growth and two required for sporulation and conferring hypersensitivity to various chemicals.

Kucharczyk R, et al. (2000 Dec). The novel protein Ccz1p required for vacuolar assembly in Saccharomyces cerevisiae functions in the same transport pathway as Ypt7p.

Kucharczyk R, et al. (2001 Sep). The Ccz1 protein interacts with Ypt7 GTPase during fusion of multiple transport intermediates with the vacuole in S. cerevisiae.

Meiling-Wesse K, et al. (2002 Aug 28). Ccz1p/Aut11p/Cvt16p is essential for autophagy and the cvt pathway.

Wang CW, et al. (2002 Dec 6). The Ccz1-Mon1 protein complex is required for the late step of multiple vacuole delivery pathways.

Wang CW, et al. (2003 Dec 8). Yeast homotypic vacuole fusion requires the Ccz1-Mon1 complex during the tethering/docking stage.

Love SL, et al. (2004 Jul 2). The yeast genes, ARL1 and CCZ1, interact to control membrane traffic and ion homeostasis.

Hoffman-Sommer M, et al. (2005 Apr 1). Multiple functions of the vacuolar sorting protein Ccz1p in Saccharomyces cerevisiae.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%