FOG18108
EOG83TXGT

sce:SDH6

Genes: 28

SGD Description
Mitochondrial protein involved in assembly of succinate dehydrogenase; has a role in maturation of the Sdh2p subunit; member of the LYR protein family; mutations in human ortholog SDHAF1 are associated with infantile leukoencephalopathy


PomBase Description
mitochondrial succinate dehydrogenase assembly factor 1 (predicted)


AspGD Description
Ortholog(s) have role in mitochondrial respiratory chain complex II assembly and mitochondrion localization


References

Blandin G, et al. (2000 Dec 22). Genomic exploration of the hemiascomycetous yeasts: 4. The genome of Saccharomyces cerevisiae revisited.

Kessler MM, et al. (2003 Feb). Systematic discovery of new genes in the Saccharomyces cerevisiae genome.

Ghezzi D, et al. (2009 Jun). SDHAF1, encoding a LYR complex-II specific assembly factor, is mutated in SDH-defective infantile leukoencephalopathy.

Na U, et al. (2014 Aug 5). The LYR factors SDHAF1 and SDHAF3 mediate maturation of the iron-sulfur subunit of succinate dehydrogenase.

Dudin O, et al. (2017 Apr). A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%