FOG18026
EOG844J16

sce:SRO77;SRO7

Genes: 34

SGD Description
Protein with roles in exocytosis and cation homeostasis; functions in docking and fusion of post-Golgi vesicles with plasma membrane; regulates cell proliferation and colony development via the Rho1-Tor1 pathway; interacts with SNARE protein Sec9p; homolog of Drosophila lethal giant larvae tumor suppressor; SRO77 has a paralog, SRO7, that arose from the whole genome duplication|Effector of Rab GTPase Sec4p; forms a complex with Sec4p and t-SNARE Sec9p; involved in exocytosis and docking and fusion of post-Golgi vesicles with plasma membrane; regulates cell proliferation and colony development via the Rho1-Tor1 pathway; homolog of Drosophila lgl tumor suppressor; SRO7 has a paralog, SRO77, that arose from the whole genome duplication


PomBase Description
Lgl family protein Sro7 (predicted)


AspGD Description
Ortholog(s) have Rab GTPase binding, SNARE binding activity and role in Golgi to plasma membrane transport, establishment of cell polarity, exocytosis, small GTPase mediated signal transduction


References

Kagami M, et al. (1998 Aug). Sro7p, a Saccharomyces cerevisiae counterpart of the tumor suppressor l(2)gl protein, is related to myosins in function.

Larsson K, et al. (1998 Dec 11). The Saccharomyces cerevisiae SOP1 and SOP2 genes, which act in cation homeostasis, can be functionally substituted by the Drosophila lethal(2)giant larvae tumor suppressor gene.

Lehman K, et al. (1999 Jul 12). Yeast homologues of tomosyn and lethal giant larvae function in exocytosis and are associated with the plasma membrane SNARE, Sec9.

Warringer J, et al. (2003 Dec 23). High-resolution yeast phenomics resolves different physiological features in the saline response.

Gangar A, et al. (2005 Jun 21). Structurally conserved interaction of Lgl family with SNAREs is critical to their cellular function.

Wadskog I, et al. (2006 Dec). The yeast tumor suppressor homologue Sro7p is required for targeting of the sodium pumping ATPase to the cell surface.

Grosshans BL, et al. (2006 Jan 2). The yeast lgl family member Sro7p is an effector of the secretory Rab GTPase Sec4p.

Hattendorf DA, et al. (2007 Mar 29). Structure of the yeast polarity protein Sro7 reveals a SNARE regulatory mechanism.

Rossi G, et al. (2011 Mar 15). Yeast homologues of lethal giant larvae and type V myosin cooperate in the regulation of Rab-dependent vesicle clustering and polarized exocytosis.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 11 genes with posterior transmembrane prediction > 50%