FOG17925
EOG84B8MJ

sce:VPH2

Genes: 28

SGD Description
Integral membrane protein required for V-ATPase function; not an actual component of the vacuolar H+-ATPase (V-ATPase) complex; functions in the assembly of the V-ATPase; localized to the endoplasmic reticulum (ER); involved in methionine restriction extension of chronological lifespan in an autophagy-dependent manner


References

Colleaux L, et al. (1992 Apr). Sequence of a segment of yeast chromosome XI identifies a new mitochondrial carrier, a new member of the G protein family, and a protein with the PAAKK motif of the H1 histones.

Bachhawat AK, et al. (1993 Feb). The VPH2 gene encodes a 25 kDa protein required for activity of the yeast vacuolar H(+)-ATPase.

Hirata R, et al. (1993 Jan 15). VMA12 is essential for assembly of the vacuolar H(+)-ATPase subunits onto the vacuolar membrane in Saccharomyces cerevisiae.

Jackson DD, et al. (1997 Oct 10). VMA12 encodes a yeast endoplasmic reticulum protein required for vacuolar H+-ATPase assembly.

Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 28 genes with posterior transmembrane prediction > 50%