FOG17904
EOG84F4RK

sce:AIP1

Genes: 32

SGD Description
Actin cortical patch component; interacts with the actin depolymerizing factor cofilin; inhibits elongation of aged ADP-actin filaments decorated with cofilin to maintain a high level of assembly-competent actin species; required to restrict cofilin localization to cortical patches; putative regulator of cytokinesis; contains WD repeats; protein increases in abundance and relocalizes from cytoplasm to plasma membrane upon DNA replication stress


PomBase Description
actin cortical patch component Aip1


AspGD Description
Ortholog(s) have cell division site, cell tip, cytosol, nucleus localization


References

Rodal AA, et al. (1999 Jun 14). Aip1p interacts with cofilin to disassemble actin filaments.

Saitoh S, et al. (2002 May 31). Cid13 is a cytoplasmic poly(A) polymerase that regulates ribonucleotide reductase mRNA.

Voegtli WC, et al. (2003 Sep 5). The structure of Aip1p, a WD repeat protein that regulates Cofilin-mediated actin depolymerization.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Deshpande GP, et al. (2009 May 1). Screening a genome-wide S. pombe deletion library identifies novel genes and pathways involved in genome stability maintenance.

Han TX, et al. (2010). Global fitness profiling of fission yeast deletion strains by barcode sequencing.

Saberianfar R, et al. (2011). Global gene expression analysis of fission yeast mutants impaired in Ser-2 phosphorylation of the RNA pol II carboxy terminal domain.

Stewart EV, et al. (2011 Apr 22). Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.

Snaith HA, et al. (2011 Jul 1). Characterization of Mug33 reveals complementary roles for actin cable-dependent transport and exocyst regulators in fission yeast exocytosis.

Chen Q, et al. (2011 Oct 31). Actin filament severing by cofilin is more important for assembly than constriction of the cytokinetic contractile ring.

Pancaldi V, et al. (2012 Apr). Predicting the fission yeast protein interaction network.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Berro J, et al. (2014 Nov 5). Synergies between Aip1p and capping protein subunits (Acp1p and Acp2p) in clathrin-mediated endocytosis and cell polarization in fission yeast.

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Dudin O, et al. (2017 Apr). A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%