FOG17869
EOG84J101

sce:IKI3

Genes: 34

SGD Description
Subunit of Elongator complex; Elongator is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)


PomBase Description
elongator subunit Elp1 (predicted)


AspGD Description
Ortholog(s) have tRNA binding activity, role in regulation of transcription from RNA polymerase II promoter, tRNA wobble uridine modification and Elongator holoenzyme complex, cytosol, nucleus localization


References

Yajima H, et al. (1997 Apr). Characterization of IKI1 and IKI3 genes conferring pGKL killer sensitivity on Saccharomyces cerevisiae.

Otero G, et al. (1999 Jan). Elongator, a multisubunit component of a novel RNA polymerase II holoenzyme for transcriptional elongation.

Frohloff F, et al. (2001 Apr 17). Saccharomyces cerevisiae Elongator mutations confer resistance to the Kluyveromyces lactis zymocin.

Winkler GS, et al. (2001 Aug 31). RNA polymerase II elongator holoenzyme is composed of two discrete subcomplexes.

Krogan NJ, et al. (2001 Dec). Characterization of a six-subunit holo-elongator complex required for the regulated expression of a group of genes in Saccharomyces cerevisiae.

Slaugenhaupt SA, et al. (2001 Mar). Tissue-specific expression of a splicing mutation in the IKBKAP gene causes familial dysautonomia.

Fichtner L, et al. (2002 Aug). Protein interactions within Saccharomyces cerevisiae Elongator, a complex essential for Kluyveromyces lactis zymocicity.

Ikebe C, et al. (2002 Feb 8). Isolation and characterization of a novel F-box protein Pof10 in fission yeast.

Winkler GS, et al. (2002 Mar 19). Elongator is a histone H3 and H4 acetyltransferase important for normal histone acetylation levels in vivo.

Frohloff F, et al. (2003 Jan 10). Subunit communications crucial for the functional integrity of the yeast RNA polymerase II elongator (gamma-toxin target (TOT)) complex.

Klassen R, et al. (2003 Nov). Structural and functional analysis of the killer element pPin1-3 from Pichia inositovora.

Huang B, et al. (2005 Apr). An early step in wobble uridine tRNA modification requires the Elongator complex.

Rahl PB, et al. (2005 Mar 18). Elp1p, the yeast homolog of the FD disease syndrome protein, negatively regulates exocytosis independently of transcriptional elongation.

Zuin A, et al. (2008 Jul 30). Mitochondrial dysfunction increases oxidative stress and decreases chronological life span in fission yeast.

Dixon SJ, et al. (2008 Oct 28). Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes.

Hanyu Y, et al. (2009 May). Schizosaccharomyces pombe cell division cycle under limited glucose requires Ssp1 kinase, the putative CaMKK, and Sds23, a PP2A-related phosphatase inhibitor.

Stewart EV, et al. (2011 Apr 22). Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.

Fang Y, et al. (2012 Apr). A genomewide screen in Schizosaccharomyces pombe for genes affecting the sensitivity of antifungal drugs that target ergosterol biosynthesis.

Bauer F, et al. (2012 May 31). Translational control of cell division by Elongator.

Fernández-Vázquez J, et al. (2013). Modification of tRNA(Lys) UUU by elongator is essential for efficient translation of stress mRNAs.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Rallis C, et al. (2014 Feb 15). Systematic screen for mutants resistant to TORC1 inhibition in fission yeast reveals genes involved in cellular ageing and growth.

Doi A, et al. (2015 Apr). Chemical genomics approach to identify genes associated with sensitivity to rapamycin in the fission yeast Schizosaccharomyces pombe.

Zhang X, et al. (2015 Oct 9). Characterization of Tamoxifen as an Antifungal Agent Using the Yeast Schizosaccharomyces Pombe Model Organism.

Gaspa L, et al. (2016). A functional genome-wide genetic screening identifies new pathways controlling the G1/S transcriptional wave.

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%