FOG17831
EOG84MW71

sce:TOP1

Genes: 34

SGD Description
Topoisomerase I; nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination; role in processing ribonucleoside monophosphates in genomic DNA into irreversible single-strand breaks


PomBase Description
DNA topoisomerase I


AspGD Description
Putative topoisomerase I


References

Thrash C, et al. (1985 Jul). Cloning, characterization, and sequence of the yeast DNA topoisomerase I gene.

Eng WK, et al. (1989 Aug 15). Mapping of the active site tyrosine of eukaryotic DNA topoisomerase I.

Lynn RM, et al. (1989 May). Peptide sequencing and site-directed mutagenesis identify tyrosine-727 as the active site tyrosine of Saccharomyces cerevisiae DNA topoisomerase I.

Lue N, et al. (1995 Dec 15). A 26 kDa yeast DNA topoisomerase I fragment: crystallographic structure and mechanistic implications.

Van Dross RT, et al. (1997 Dec 12). Cloning and characterization of the Aspergillus nidulans DNA topoisomerase I gene.

Goldman GH, et al. (1997 May 27). Differential poisoning of human and Aspergillus nidulans DNA topoisomerase I by bi- and terbenzimidazoles.

Fagundes MR, et al. (2003 Jul). Identification of a topoisomerase I mutant, scsA1, as an extragenic suppressor of a mutation in scaA(NBS1), the apparent homolog of human nibrin in Aspergillus nidulans.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%