FOG17816
EOG84MW93

sce:SDS3

Genes: 27

SGD Description
Component of the Rpd3L histone deacetylase complex; required for its structural integrity and catalytic activity, involved in transcriptional silencing and required for sporulation; relocalizes to the cytosol in response to hypoxia; cells defective in SDS3 display pleiotropic phenotypes


References

Vannier D, et al. (1996 Dec). Evidence that the transcriptional regulators SIN3 and RPD3, and a novel gene (SDS3) with similar functions, are involved in transcriptional silencing in S. cerevisiae.

Lechner T, et al. (2000 Dec 29). Sds3 (suppressor of defective silencing 3) is an integral component of the yeast Sin3[middle dot]Rpd3 histone deacetylase complex and is required for histone deacetylase activity.

Dorland S, et al. (2000 Feb). Roles for the Saccharomyces cerevisiae SDS3, CBK1 and HYM1 genes in transcriptional repression by SIN3.

Vannier D, et al. (2001 May). A role for Sds3p, a component of the Rpd3p/Sin3p deacetylase complex, in maintaining cellular integrity in Saccharomyces cerevisiae.

Nourani A, et al. (2003 May 23). Opposite role of yeast ING family members in p53-dependent transcriptional activation.

Carrozza MJ, et al. (2005 Nov 10). Stable incorporation of sequence specific repressors Ash1 and Ume6 into the Rpd3L complex.

Keogh MC, et al. (2005 Nov 18). Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%