FOG17786
EOG84QRHG

sce:MMM1

Genes: 35

SGD Description
ER integral membrane protein, ERMES complex subunit; ERMES links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth; required for mitophagy; ERMES complex is often co-localized with peroxisomes and with concentrated areas of pyruvate dehydrogenase


PomBase Description
ERMES complex subunit Mmm1 (predicted)


AspGD Description
Ortholog(s) have role in hyphal growth, mitochondrial genome maintenance, mitochondrial outer membrane translocase complex assembly, mitochondrion-ER tethering and phospholipid transport, more


References

Burgess SM, et al. (1994 Sep). MMM1 encodes a mitochondrial outer membrane protein essential for establishing and maintaining the structure of yeast mitochondria.

Boldogh I, et al. (1998 Jun 15). Interaction between mitochondria and the actin cytoskeleton in budding yeast requires two integral mitochondrial outer membrane proteins, Mmm1p and Mdm10p.

Hobbs AE, et al. (2001 Jan 22). Mmm1p, a mitochondrial outer membrane protein, is connected to mitochondrial DNA (mtDNA) nucleoids and required for mtDNA stability.

Hanekamp T, et al. (2002 Nov). Maintenance of mitochondrial morphology is linked to maintenance of the mitochondrial genome in Saccharomyces cerevisiae.

Kondo-Okamoto N, et al. (2003 Dec 5). Mmm1p spans both the outer and inner mitochondrial membranes and contains distinct domains for targeting and foci formation.

Boldogh IR, et al. (2003 Nov). A protein complex containing Mdm10p, Mdm12p, and Mmm1p links mitochondrial membranes and DNA to the cytoskeleton-based segregation machinery.

Sickmann A, et al. (2003 Nov 11). The proteome of Saccharomyces cerevisiae mitochondria.

Youngman MJ, et al. (2004 Mar 1). Mmm2p, a mitochondrial outer membrane protein required for yeast mitochondrial shape and maintenance of mtDNA nucleoids.

Zahedi RP, et al. (2006 Mar). Proteomic analysis of the yeast mitochondrial outer membrane reveals accumulation of a subclass of preproteins.

Meisinger C, et al. (2007 May 2). The morphology proteins Mdm12/Mmm1 function in the major beta-barrel assembly pathway of mitochondria.

Kornmann B, et al. (2009 Jul 24). An ER-mitochondria tethering complex revealed by a synthetic biology screen.

Rhind N, et al. (2011 May 20). Comparative functional genomics of the fission yeasts.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 33 genes with posterior transmembrane prediction > 50%