FOG17757
EOG84TMPV

sce:MGM1

Genes: 35

SGD Description
Mitochondrial GTPase, present in complex with Ugo1p and Fzo1p; required for mitochondrial morphology, fusion, and genome maintenance; exists as long and short form with different distributions; ratio of long to short forms is regulated by Psd1p; homolog of human OPA1 involved in autosomal dominant optic atrophy


PomBase Description
mitochondrial dynamin family GTPase Msp1


AspGD Description
Ortholog(s) have role in mitochondrial fusion, mitochondrial genome maintenance and extrinsic component of mitochondrial inner membrane, fungal-type vacuole membrane localization


References

Jones BA, et al. (1992 Mar). Mitochondrial DNA maintenance in yeast requires a protein containing a region related to the GTP-binding domain of dynamin.

Guan K, et al. (1993 Jul-Aug). Normal mitochondrial structure and genome maintenance in yeast requires the dynamin-like product of the MGM1 gene.

Lalo D, et al. (1993 Jun 15). Interactions between three common subunits of yeast RNA polymerases I and III.

Shepard KA, et al. (1999 Feb 22). The yeast dynamin-like protein, Mgm1p, functions on the mitochondrial outer membrane to mediate mitochondrial inheritance.

Wong ED, et al. (2003 Feb 3). The intramitochondrial dynamin-related GTPase, Mgm1p, is a component of a protein complex that mediates mitochondrial fusion.

Herlan M, et al. (2003 Jul 25). Processing of Mgm1 by the rhomboid-type protease Pcp1 is required for maintenance of mitochondrial morphology and of mitochondrial DNA.

Sesaki H, et al. (2003 Jun). Mgm1p, a dynamin-related GTPase, is essential for fusion of the mitochondrial outer membrane.

Herlan M, et al. (2004 Apr 26). Alternative topogenesis of Mgm1 and mitochondrial morphology depend on ATP and a functional import motor.

Sesaki H, et al. (2004 Jul 2). Ugo1p links the Fzo1p and Mgm1p GTPases for mitochondrial fusion.

Zahedi RP, et al. (2006 Mar). Proteomic analysis of the yeast mitochondrial outer membrane reveals accumulation of a subclass of preproteins.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 9 genes with posterior transmembrane prediction > 50%