FOG17677
EOG851C5X

sce:SEC23

Genes: 57

SGD Description
GTPase-activating protein, stimulates the GTPase activity of Sar1p; component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, involved in ER to Golgi transport; substrate of Ubp3/Bre5 complex; ubiquitylated by Ub-ligase Rsp5p; proteasome-mediated degradation of Sec23p is regulated by Cdc48p


PomBase Description
COPII cargo receptor subunit Sec23a (predicted)|COPII cargo receptor subunit Sec23b (predicted)


AspGD Description
COPII complexn subunit; expression enhanced by maltose


References

Novick P, et al. (1980 Aug). Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway.

Novick P, et al. (1981 Aug). Order of events in the yeast secretory pathway.

Baker D, et al. (1988 Jul 29). Reconstitution of SEC gene product-dependent intercompartmental protein transport.

Ruohola H, et al. (1988 Oct). Reconstitution of protein transport from the endoplasmic reticulum to the Golgi complex in yeast: the acceptor Golgi compartment is defective in the sec23 mutant.

Hicke L, et al. (1989 Jun). Yeast Sec23p acts in the cytoplasm to promote protein transport from the endoplasmic reticulum to the Golgi complex in vivo and in vitro.

Kaiser CA, et al. (1990 May 18). Distinct sets of SEC genes govern transport vesicle formation and fusion early in the secretory pathway.

Hicke L, et al. (1992 Jun). Sec23p and a novel 105-kDa protein function as a multimeric complex to promote vesicle budding and protein transport from the endoplasmic reticulum.

Liang S, et al. (1993 Dec). Multicopy STS1 restores both protein transport and ribosomal RNA stability in a new yeast sec23 mutant allele.

Yoshihisa T, et al. (1993 Mar 5). Requirement for a GTPase-activating protein in vesicle budding from the endoplasmic reticulum.

Bednarek SY, et al. (1995 Dec 29). COPI- and COPII-coated vesicles bud directly from the endoplasmic reticulum in yeast.

Espenshade P, et al. (1995 Oct). Yeast SEC16 gene encodes a multidomain vesicle coat protein that interacts with Sec23p.

Gimeno RE, et al. (1996 Nov). COPII coat subunit interactions: Sec24p and Sec23p bind to adjacent regions of Sec16p.

Kuehn MJ, et al. (1996 Nov). Amino acid permeases require COPII components and the ER resident membrane protein Shr3p for packaging into transport vesicles in vitro.

Campbell JL, et al. (1997 Feb 4). Selective packaging of cargo molecules into endoplasmic reticulum-derived COPII vesicles.

Sütterlin C, et al. (1997 Nov). Specific requirements for the ER to Golgi transport of GPI-anchored proteins in yeast.

Shaywitz DA, et al. (1997 Oct 10). COPII subunit interactions in the assembly of the vesicle coat.

Matsuoka K, et al. (1998 Apr 17). COPII-coated vesicle formation reconstituted with purified coat proteins and chemically defined liposomes.

Kuehn MJ, et al. (1998 Jan 8). COPII-cargo interactions direct protein sorting into ER-derived transport vesicles.

Springer S, et al. (1998 Jul 31). Nucleation of COPII vesicular coat complex by endoplasmic reticulum to Golgi vesicle SNAREs.

Morin-Ganet MN, et al. (1998 Jun). Role of endoplasmic reticulum-derived vesicles in the formation of Golgi elements in sec23 and sec18 Saccharomyces Cerevisiae mutants.

Peñalver E, et al. (1999 Apr). Clathrin and two components of the COPII complex, Sec23p and Sec24p, could be involved in endocytosis of the Saccharomyces cerevisiae maltose transporter.

Gilstring CF, et al. (1999 Nov). Shr3p mediates specific COPII coatomer-cargo interactions required for the packaging of amino acid permeases into ER-derived transport vesicles.

Matsuoka K, et al. (2000 Apr). The use of liposomes to study COPII- and COPI-coated vesicle formation and membrane protein sorting.

Kurihara T, et al. (2000 Mar). Sec24p and Iss1p function interchangeably in transport vesicle formation from the endoplasmic reticulum in Saccharomyces cerevisiae.

Shimoni Y, et al. (2000 Nov 27). Lst1p and Sec24p cooperate in sorting of the plasma membrane ATPase into COPII vesicles in Saccharomyces cerevisiae.

Votsmeier C, et al. (2001 Dec 3). An acidic sequence of a putative yeast Golgi membrane protein binds COPII and facilitates ER export.

Antonny B, et al. (2001 Jun). Dynamics of the COPII coat with GTP and stable analogues.

Belden WJ, et al. (2001 Nov 16). Distinct roles for the cytoplasmic tail sequences of Emp24p and Erv25p in transport between the endoplasmic reticulum and Golgi complex.

Matsuoka K, et al. (2001 Nov 20). Surface structure of the COPII-coated vesicle.

Lederkremer GZ, et al. (2001 Sep 11). Structure of the Sec23p/24p and Sec13p/31p complexes of COPII.

Supek F, et al. (2002 Sep 16). Sec16p potentiates the action of COPII proteins to bud transport vesicles.

Bi X, et al. (2002 Sep 19). Structure of the Sec23/24-Sar1 pre-budding complex of the COPII vesicle coat.

Antonny B, et al. (2003 Apr). Self-assembly of minimal COPII cages.

Mossessova E, et al. (2003 Aug 22). SNARE selectivity of the COPII coat.

Cohen M, et al. (2003 Jul). Ubp3 requires a cofactor, Bre5, to specifically de-ubiquitinate the COPII protein, Sec23.

Muthuvijayan V, et al. (2004). In silico reconstruction of nutrient-sensing signal transduction pathways in Aspergillus nidulans.

Sato K, et al. (2004 Jan 9). Reconstitution of coat protein complex II (COPII) vesicle formation from cargo-reconstituted proteoliposomes reveals the potential role of GTP hydrolysis by Sar1p in protein sorting.

Schuldiner M, et al. (2005 Nov 4). Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile.

Cai H, et al. (2007 Feb 22). TRAPPI tethers COPII vesicles by binding the coat subunit Sec23.

Behnia R, et al. (2007 Jan 29). The yeast orthologue of GRASP65 forms a complex with a coiled-coil protein that contributes to ER to Golgi traffic.

Pantazopoulou A, et al. (2009 Oct). Organization and dynamics of the Aspergillus nidulans Golgi during apical extension and mitosis.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Yehia L, et al. (2015 Nov 5). Germline Heterozygous Variants in SEC23B Are Associated with Cowden Syndrome and Enriched in Apparently Sporadic Thyroid Cancer.

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 9 genes with posterior transmembrane prediction > 50%