FOG17664
EOG851C7S

sce:CTR1

Genes: 26

SGD Description
High-affinity copper transporter of the plasma membrane; mediates nearly all copper uptake under low copper conditions; transcriptionally induced at low copper levels and degraded at high copper levels; protein increases in abundance and relocalizes from nucleus to plasma membrane upon DNA replication stress


References

Dancis A, et al. (1994 Jan 28). Molecular characterization of a copper transport protein in S. cerevisiae: an unexpected role for copper in iron transport.

Dancis A, et al. (1994 Oct 14). The Saccharomyces cerevisiae copper transport protein (Ctr1p). Biochemical characterization, regulation by copper, and physiologic role in copper uptake.

Lane S, et al. (2001 Dec 28). DNA array studies demonstrate convergent regulation of virulence factors by Cph1, Cph2, and Efg1 in Candida albicans.

Nantel A, et al. (2002 Oct). Transcription profiling of Candida albicans cells undergoing the yeast-to-hyphal transition.

Marvin ME, et al. (2003 Jun). The Candida albicans CTR1 gene encodes a functional copper transporter.

Bensen ES, et al. (2004 Dec). Transcriptional profiling in Candida albicans reveals new adaptive responses to extracellular pH and functions for Rim101p.

Marvin ME, et al. (2004 Jul). The CaCTR1 gene is required for high-affinity iron uptake and is transcriptionally controlled by a copper-sensing transactivator encoded by CaMAC1.

Lorenz MC, et al. (2004 Oct). Transcriptional response of Candida albicans upon internalization by macrophages.

Singh V, et al. (2005 Sep 9). Global analysis of altered gene expression during morphogenesis of Candida albicans in vitro.

Cheng G, et al. (2006 Jan). Cellular and molecular biology of Candida albicans estrogen response.

Cabezón V, et al. (2009 Oct). Analysis of Candida albicans plasma membrane proteome.

Bonhomme J, et al. (2011 May). Contribution of the glycolytic flux and hypoxia adaptation to efficient biofilm formation by Candida albicans.

Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.

Schwartz JA, et al. (2013 Jul). Regulation of copper toxicity by Candida albicans GPA2.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 26 genes with posterior transmembrane prediction > 50%