FOG17639
EOG8547F8

sce:TOM70;TOM71

Genes: 34

SGD Description
Component of the TOM (translocase of outer membrane) complex; involved in the recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins; TOM70 has a paralog, TOM71, that arose from the whole genome duplication|Mitochondrial outer membrane protein; probable minor component of the TOM (translocase of outer membrane) complex responsible for recognition and import of mitochondrially directed proteins; TOM71 has a paralog, TOM70, that arose from the whole genome duplication


PomBase Description
mitochondrial TOM complex subunit Tom70 (predicted)


AspGD Description
Ortholog(s) have preprotein binding activity, role in conidium formation, hyphal growth, protein targeting to mitochondrion and mitochondrial outer membrane translocase complex localization


References

Hase T, et al. (1983). Import of proteins into mitochondria: nucleotide sequence of the gene for a 70-kd protein of the yeast mitochondrial outer membrane.

Boguski MS, et al. (1990 Jul 12). Expanding family.

Hines V, et al. (1990 Oct). Protein import into yeast mitochondria is accelerated by the outer membrane protein MAS70.

Hines V, et al. (1993 Jan 5). Precursor binding to yeast mitochondria. A general role for the outer membrane protein Mas70p.

Schlossmann J, et al. (1996 Jul 26). Tom71, a novel homologue of the mitochondrial preprotein receptor Tom70.

Bömer U, et al. (1996 Mar 11). Identification of a third yeast mitochondrial Tom protein with tetratrico peptide repeats.

Dekker PJ, et al. (1998 Nov). Preprotein translocase of the outer mitochondrial membrane: molecular dissection and assembly of the general import pore complex.

van Wilpe S, et al. (1999 Sep 30). Tom22 is a multifunctional organizer of the mitochondrial preprotein translocase.

Brix J, et al. (2000 Nov 3). The mitochondrial import receptor Tom70: identification of a 25 kDa core domain with a specific binding site for preproteins.

Grandier-Vazeille X, et al. (2001 Aug 21). Yeast mitochondrial dehydrogenases are associated in a supramolecular complex.

Sickmann A, et al. (2003 Nov 11). The proteome of Saccharomyces cerevisiae mitochondria.

Burri L, et al. (2006 Apr). Integral membrane proteins in the mitochondrial outer membrane of Saccharomyces cerevisiae.

Zahedi RP, et al. (2006 Mar). Proteomic analysis of the yeast mitochondrial outer membrane reveals accumulation of a subclass of preproteins.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Kondo-Okamoto N, et al. (2008 Jan). Tetratricopeptide repeat proteins Tom70 and Tom71 mediate yeast mitochondrial morphogenesis.

Sinha H, et al. (2008 Nov). Sequential elimination of major-effect contributors identifies additional quantitative trait loci conditioning high-temperature growth in yeast.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 23 genes with posterior transmembrane prediction > 50%