FOG17597
EOG8573R0

sce:SEC17

Genes: 32

SGD Description
Alpha-SNAP cochaperone; SNARE-complex adaptor for Sec18 (NSF) during the disassembly of postfusion cis-SNARE complexes; stimulates the ATPase activity of Sec18p; peripheral membrane protein required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, and autophagy; similar to mammalian alpha-SNAP


PomBase Description
alpha SNAP (predicted)


AspGD Description
Ortholog(s) have role in negative regulation of G0 to G1 transition


References

Griff IC, et al. (1992 Jun 15). The yeast SEC17 gene product is functionally equivalent to mammalian alpha-SNAP protein.

Mayer A, et al. (1996 Apr 5). Sec18p (NSF)-driven release of Sec17p (alpha-SNAP) can precede docking and fusion of yeast vacuoles.

Haas A, et al. (1996 Jul 1). Homotypic vacuole fusion requires Sec17p (yeast alpha-SNAP) and Sec18p (yeast NSF).

Nichols BJ, et al. (1997 May 8). Homotypic vacuolar fusion mediated by t- and v-SNAREs.

Rice LM, et al. (1999 Jul). Crystal structure of the vesicular transport protein Sec17: implications for SNAP function in SNARE complex disassembly.

Muthuvijayan V, et al. (2004). In silico reconstruction of nutrient-sensing signal transduction pathways in Aspergillus nidulans.

Collins KM, et al. (2005 May 18). Sec17p and HOPS, in distinct SNARE complexes, mediate SNARE complex disruption or assembly for fusion.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Sajiki K, et al. (2009 May 1). Genetic control of cellular quiescence in S. pombe.

Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%