FOG17378
EOG85TB4T

sce:CBF2

Genes: 5

SGD Description
Essential kinetochore protein; component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere; Cbf2p also binds to the CDEII region possibly forming a different multimeric complex, ubiquitinated in vivo; sumoylated in an Mms21p-dependent manner; relative distribution to the spindle pole body decreases upon DNA replication stress


References

Goh PY, et al. (1993 May). NDC10: a gene involved in chromosome segregation in Saccharomyces cerevisiae.

Jiang W, et al. (1993 May). Isolation and characterization of a gene (CBF2) specifying a protein component of the budding yeast kinetochore.

Zeng X, et al. (1999 Jul 26). Slk19p is a centromere protein that functions to stabilize mitotic spindles.

Ortiz J, et al. (1999 May 1). A putative protein complex consisting of Ctf19, Mcm21, and Okp1 represents a missing link in the budding yeast kinetochore.

Rodrigo-Brenni MC, et al. (2004 Jul). Sgt1p and Skp1p modulate the assembly and turnover of CBF3 complexes required for proper kinetochore function.

Cho US, et al. (2011 Dec 4). Ndc10 is a platform for inner kinetochore assembly in budding yeast.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%