FOG17304
EOG8612M7

sce:GCD2

Genes: 33

SGD Description
Delta subunit of the translation initiation factor eIF2B; the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression


PomBase Description
translation initiation factor eIF2B delta subunit (predicted)


AspGD Description
Ortholog(s) have cytosol, nucleus localization


References

Paddon CJ, et al. (1989 Jul). Amino acid sequence similarity between GCN3 and GCD2, positive and negative translational regulators of GCN4: evidence for antagonism by competition.

Cigan AM, et al. (1993 Jun 1). A protein complex of translational regulators of GCN4 mRNA is the guanine nucleotide-exchange factor for translation initiation factor 2 in yeast.

Pavitt GD, et al. (1998 Feb 15). eIF2 independently binds two distinct eIF2B subcomplexes that catalyze and regulate guanine-nucleotide exchange.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 5 genes with posterior transmembrane prediction > 50%