FOG17264
EOG863XX2

sce:ADD66

Genes: 26

SGD Description
Protein involved in 20S proteasome assembly; forms a heterodimer with Pba1p that binds to proteasome precursors; interaction with Pba1p-Add66p may affect function of the mature proteasome and its role in maintaining respiratory metabolism; similar to human PAC2 constituent of the PAC1-PAC2 complex involved in proteasome assembly


References

Palmer EA, et al. (2003 Jun 1). Differential requirements of novel A1PiZ degradation deficient (ADD) genes in ER-associated protein degradation.

Le Tallec B, et al. (2007 Aug 17). 20S proteasome assembly is orchestrated by two distinct pairs of chaperones in yeast and in mammals.

Li X, et al. (2007 May 2). beta-Subunit appendages promote 20S proteasome assembly by overcoming an Ump1-dependent checkpoint.

Scott CM, et al. (2007 Oct). ADD66, a gene involved in the endoplasmic reticulum-associated degradation of alpha-1-antitrypsin-Z in yeast, facilitates proteasome activity and assembly.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%