FOG17226
EOG866T4J

sce:MAF1

Genes: 31

SGD Description
Highly conserved negative regulator of RNA polymerase III; involved in tRNA processing and stability; inhibits tRNA degradation via rapid tRNA decay (RTD) pathway; binds N-terminal domain of Rpc160p subunit of Pol III to prevent closed-complex formation; regulated by phosphorylation mediated by TORC1, protein kinase A, Sch9p, casein kinase 2; localizes to cytoplasm during vegetative growth and translocates to nucleus and nucleolus under stress conditions


PomBase Description
repressor of RNA polymerase III Maf1


AspGD Description
Ortholog(s) have role in negative regulation of transcription from RNA polymerase III promoter, transcription factor TFIIIB complex assembly


References

Boguta M, et al. (1997 Feb 7). Mutation in a new gene MAF1 affects tRNA suppressor efficiency in Saccharomyces cerevisiae.

Upadhya R, et al. (2002 Dec). Maf1 is an essential mediator of diverse signals that repress RNA polymerase III transcription.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Soulard A, et al. (2010 Oct 1). The rapamycin-sensitive phosphoproteome reveals that TOR controls protein kinase A toward some but not all substrates.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%