FOG17116
EOG86HDTS

sce:HAP2

Genes: 29

SGD Description
Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex; complex is heme-activated and glucose-repressed; complex is a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding


PomBase Description
CCAAT-binding factor complex subunit Php2


AspGD Description
Ortholog(s) have sequence-specific DNA binding, transcription factor activity, sequence-specific DNA binding activity


References

Pinkham JL, et al. (1987 Feb). Sequence and nuclear localization of the Saccharomyces cerevisiae HAP2 protein, a transcriptional activator.

Olesen JT, et al. (1991 Feb). The Schizosaccharomyces pombe homolog of Saccharomyces cerevisiae HAP2 reveals selective and stringent conservation of the small essential core protein domain.

Xing Y, et al. (1993 Dec). Mutations in yeast HAP2/HAP3 define a hybrid CCAAT box binding domain.

Nguyen C, et al. (1995 Jan 11). The respiratory system of Kluyveromyces lactis escapes from HAP2 control.

Li Y, et al. (2001 Aug 10). A multiprotein complex that interacts with RNA polymerase II elongator.

Janoo RT, et al. (2001 Mar). Transcriptional regulators of the Schizosaccharomyces pombe fbp1 gene include two redundant Tup1p-like corepressors and the CCAAT binding factor activation complex.

Stebbins JL, et al. (2004 Apr). Identification, mutational analysis, and coactivator requirements of two distinct transcriptional activation domains of the Saccharomyces cerevisiae Hap4 protein.

McNabb DS, et al. (2005 Nov). Assembly of the Hap2p/Hap3p/Hap4p/Hap5p-DNA complex in Saccharomyces cerevisiae.

Mercier A, et al. (2006 Nov). A transcription factor cascade involving Fep1 and the CCAAT-binding factor Php4 regulates gene expression in response to iron deficiency in the fission yeast Schizosaccharomyces pombe.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Takuma K, et al. (2013). The fission yeast php2 mutant displays a lengthened chronological lifespan.

Vachon L, et al. (2013 Aug). Functional characterization of fission yeast transcription factors by overexpression analysis.

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%