FOG17045
EOG86Q57H

sce:KEX2

Genes: 36

SGD Description
Kexin, a subtilisin-like protease (proprotein convertase); a calcium-dependent serine protease involved in the activation of proproteins of the secretory pathway


PomBase Description
kexin


AspGD Description
Putative kexin; furin-type endoprotease; endoproteolytic proprotein processing enzyme; processes dibasic cleavage sites in target proteins destined for secretory pathway; required for maturation of glucoamylase


References

Tanguy-Rougeau C, et al. (1988 Jul 18). The Kluyveromyces lactis KEX1 gene encodes a subtilisin-type serine proteinase.

Mizuno K, et al. (1988 Oct 14). Yeast KEX2 genes encodes an endopeptidase homologous to subtilisin-like serine proteases.

Fuller RS, et al. (1989 Mar). Yeast prohormone processing enzyme (KEX2 gene product) is a Ca2+-dependent serine protease.

Wilcox CA, et al. (1991 Oct). Posttranslational processing of the prohormone-cleaving Kex2 protease in the Saccharomyces cerevisiae secretory pathway.

Brenner C, et al. (1992 Feb 1). Structural and enzymatic characterization of a purified prohormone-processing enzyme: secreted, soluble Kex2 protease.

Germain D, et al. (1992 Mar 16). The pro-region of the Kex2 endoprotease of Saccharomyces cerevisiae is removed by self-processing.

Enderlin CS, et al. (1994 Jan). Cloning, nucleotide sequence and functions of XPR6, which codes for a dibasic processing endoprotease from the yeast Yarrowia lipolytica.

Newport G, et al. (1997 Nov 14). KEX2 influences Candida albicans proteinase secretion and hyphal formation.

Kwon BK, et al. (2001 Aug 31). Molecular cloning of kpcA gene encoding a Kex2p-like endoprotease from Aspergillus nidulans.

Holyoak T, et al. (2003 Jun 10). 2.4 A resolution crystal structure of the prototypical hormone-processing protease Kex2 in complex with an Ala-Lys-Arg boronic acid inhibitor.

Mizutani O, et al. (2004 Aug). Disordered cell integrity signaling caused by disruption of the kexB gene in Aspergillus oryzae.

Mizutani O, et al. (2009 Jan). Alternative processing of proproteins in Aspergilli kexB gene disruptants under hyperosmotic conditions.

Harris SD, et al. (2009 Mar). Morphology and development in Aspergillus nidulans: a complex puzzle.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 35 genes with posterior transmembrane prediction > 50%